Tranilast

製品コードS1439 バッチS143902

印刷

化学情報

Chemical Structure Synonyms SB 252218, MK-341 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C18H17NO5
分子量 327.33 CAS No. 53902-12-8
Solubility (25°C)* 体外 DMSO 66 mg/mL (201.63 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Tranilastは、炎症細胞からの脂質メディエーターおよびサイトカイン放出を阻害することにより、抗アレルギー薬として喘息、アレルギー性鼻炎、アトピー性皮膚炎などのアレルギー疾患の治療に用いられます。
in vitro Tranilast is an anti-allergic drug inhibiting the release of substances such as histamine and prostaglandins from mast cells, which suppresses collagen synthesis of fibroblasts derived from keloid tissues. This compound (3-300 mM) suppresses the collagen synthesis of fibroblasts from keloid and hypertrophic scar tissue but not healthy skin fibroblasts. It (30-300 mM) inhibits the release of transforming growth factor (TGF)-beta 1 from keloid fibroblasts, which enhances the collagen synthesis of keloid fibroblasts. This drug improves keloids and hypertrophic scars which originate from the abnormal proliferation and excessive collagen accumulation of fibroblasts. It inhibits the release of TGF-beta 1, IL-1 beta and PGE2 from the human monocytes-macrophages. This chemical inhibits the proliferation stimulated with fetal bovine serum (FBS), TGF-beta 1 and platelet-derived growth factor-BB (PDGF-BB) as well as PDGF-BB-induced migration. It exhibits inhibitory effects on spontaneous collagen synthesis and TGF-beta 1-induced collagen and glycosaminoglycan synthesis.
in vivo Tranilast results in a 58% reduction in TGF-beta1-induced 3[H]-hydroxyproline incorporation in the diabetic heart of rats. This compound attenuates cardiac fibrosis by 37% in association with reduction in phospho-Smad2 in the diabetic heart of rats. It completely prevents the increase in chymaselike activity, reduces the chymase mRNA levels by 43%, and decreases the carotid intima/media ratio by 63% in the carotid artery of dogs.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/1282576/
  • https://pubmed.ncbi.nlm.nih.gov/1282575/
  • https://pubmed.ncbi.nlm.nih.gov/8770315/
  • https://pubmed.ncbi.nlm.nih.gov/15664396/
  • https://pubmed.ncbi.nlm.nih.gov/10051304/

カスタマーフィードバック

, , Environ Toxicol Pharmacol, 2015, 39(1):114-124.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors [ EMBO Mol Med, 2025, 17(4):747-774] PubMed: 40055574
HBx promotes podocyte-macrophage transdifferentiation by mediating NLRP3 expression in hepatitis B virus-associated glomerulonephritis [ Virol J, 2025, 22(1):301] PubMed: 40999437
Restoration of angiogenic capacity in senescent endothelial cells by a pharmacological reprogramming approach [ PLoS One, 2025, 20(2):e0319381] PubMed: 40019880
Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable [ Antiviral Res, 2023, 216:105674] PubMed: 37459896
Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19 [ iScience, 2023, 26(6):106929] PubMed: 37260746
Tranilast reduces cardiomyocyte injury induced by ischemia‑reperfusion via Nrf2/HO‑1/NF‑κB signaling [ Exp Ther Med, 2023, 25(4):160] PubMed: 36911371
Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling [ Sci Adv, 2023, 9(27):eadg9593] PubMed: 37418519
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258] PubMed: 35207746
Establishment and characterization of NCC-UPS4-C1: a novel cell line of undifferentiated pleomorphic sarcoma from a patient with Li-Fraumeni syndrome [ Hum Cell, 2022, 10.1007/s13577-022-00671-y] PubMed: 35118583
Establishment and characterization of novel patient-derived cell lines from giant cell tumor of bone [ Hum Cell, 2021, 10.1007/s13577-021-00579-z] PubMed: 34304386

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。