Retinoic acid (Tretinoin)

製品コードS1653 バッチs165302

化学情報

	Synonyms	All-trans Retinoic Acid, ATRA, Vitamin A acid,NSC 122758	Storage (From the date of receipt)	3 years -20°C(in the dark) powder
	化学式	C₂₀H₂₈O₂
	分子量	300.4	CAS No.	302-79-4
Solubility (25°C)*	体外	DMSO	60 mg/mL (199.73 mM)
		Ethanol	6 mg/mL (19.97 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Retinoic acid (Tretinoin), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
in vitro	Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. ^[1] Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. ^[2]
in vivo	Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. ^[1] Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. ^[3] Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. ^[4] Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. ^[5]

製品説明

Retinoic acid (Tretinoin), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

in vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. ^[1]

Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. ^[2]

in vivo

Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. ^[1]

Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. ^[3]

Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. ^[4]

Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. ^[5]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BE2C cells
	濃度	5 μM
	反応時間	6 days
	実験の流れ	Cells were treated with indicated concentration of drug for 6 days.
動物実験	動物モデル	Female Skh-hairless-1 albino mice
	投薬量	0.05%
	投与方法	Dorsal application

参考

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カスタマーフィードバック

: Data from [Data independently produced by , , Cell, 2018, 175(5):1244-1258]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The Effect of Retinoic Acid on Arsenite-Transformed Malignant UROtsa Bladder Cancer Cells: In Vitro Model of Basal Muscle-Invasive Bladder Cancer [ Cancers (Basel), 2024, 16(6)1178]	PubMed: 38539513
Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage [ Cell Res, 2023, 33(6):421-433]	PubMed: 37085732
Generation of human otic neuronal organoids using pluripotent stem cells [ Cell Prolif, 2023, 56(5):e13434]	PubMed: 36825797
Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion [ Phytomedicine, 2023, 118:154942]	PubMed: 37421767
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system [ J Cell Sci, 2023, 136(6)jcs259875]	PubMed: 36825945
The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system [ J Cell Sci, 2023, 136(6)jcs259875]	PubMed: 36825945
Dynamic Plasticity Systems Direct Early Adaptation to Treatment in Neuroblastoma [ bioRxiv, 2023, 10.1101/2023.12.07.570359]	PubMed: none
Isolation of Reporter Cells That Respond to Vitamin A and/or D Using a piggyBac Transposon Promoter-Trapping Vector System [ Int J Mol Sci, 2022, 23(16)9366]	PubMed: 36012634
Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei [ J Pers Med, 2022, 12(2)258]	PubMed: 35207746
ATRA-mediated-crosstalk between stellate cells and Kupffer cells inhibits autophagy and promotes NLRP3 activation in acute liver injury [ Cell Signal, 2022, 93:110304]	PubMed: 35278669

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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