Vidarabine

製品コードS1784 バッチS178402

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₀H₁₃N₅O₄

分子量

267.24

CAS No.

5536-17-4

Solubility (25°C)*

体外

DMSO

53 mg/mL (198.32 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	2.65mg/ml (9.92mM)	Taking the 1 mL working solution as an example, add 50 μL of 53 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5 %DMSO 1 95 %Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.38mg/ml (1.42mM)	Taking the 1 mL working solution as an example, add 50 μL of 7.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Vidarabineは、ウイルスDNAの合成を妨害することにより、単純ヘルペスウイルスおよび水痘帯状疱疹ウイルスの治療に使用される抗ウイルス薬です。
in vitro	Vidarabine and Acyclovir have a synergistic effect on wild type. This compound is capable of inhibiting acyclovir-resistant/TK-deficient mutants of HSV and VZV, because it is phosphorylated to its active vidarabine–triphosphate form by cellular kinases and is not dependent for its activation on the viral TK. This compound and acyclovir (ACV) alone show a concentration-dependent inhibition of plaque formation of HSV-1 in Vero cells. It combined with acidic protein bound polysaccharide (APBP) show synergistic effects on the plaque formation of HSV-1 in Vero cells. It acts directly on the DNA polymerase of varicella-zoster virus (VZV) and double-strand DNA viruses, including human adenoviruses. This chemical specifically inhibits adenovirus type 11 replication without obvious cytotoxicity in vitro. It acts less on the synthesis of early proteins but rather on those after DNA replication. It is an antiviral drug with activity against herpes viruses, poxviruses, and certain rhabdoviruses, hepadnarviruses, and RNA tumor viruses. It also is active against vaccinia virus both in vitro and in vivo.
in vivo	Vididarabine is rapidly deaminated to 9-β-D-arabinofuranosyl hypoxanthine (Ara-Hx) as the principal metabolite.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/16797734/
https://pubmed.ncbi.nlm.nih.gov/10967475/
https://pubmed.ncbi.nlm.nih.gov/15535050/

https://pubmed.ncbi.nlm.nih.gov/19097789/

+ 展开

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Identifying novel radioprotective drugs via salivary gland tissue chip screening [ bioRxiv, July 13, 2023, 2023.07.12.548707]	PubMed: 37503292
Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation. [ Neuron, 2017, 96(6):1290-1302]	PubMed: 29268096
Rational Design of a Profluorescent Substrate for S-adenosylhomocysteine Hydrolase and its Applications in Bioimaging and Inhibitor Screening. [ ACS Appl Mater Interfaces, 2016, 8(39):25818-25824]	PubMed: 27626909
Repurposing FDA-approved drugs for anti-aging therapies. [ Biogerontology, 2016, 17(5-6):907-920]	PubMed: 27484416

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。