Vidarabine

製品コードS1784 バッチS178402

化学情報

	Synonyms	N/A	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₀H₁₃N₅O₄
	分子量	267.24	CAS No.	5536-17-4
Solubility (25°C)*	体外	DMSO	53 mg/mL (198.32 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.
in vitro	Vidarabine and Acyclovir have a synergistic effect on wild type . Vidarabine is capable of inhibiting acyclovir-resistant/TK-deficient mutants of HSV and VZV, because it is phosphorylated to its active vidarabine–triphosphate form by cellular kinases and is not dependent for its activation on the viral TK. ^[1] Vidarabine and acyclovir (ACV) alone show a concentration-dependent inhibition of plaque formation of HSV-1 in Vero cells. Vidarabine combined with acidic protein bound polysaccharide (APBP) show synergistic effects on the plaque formation of HSV-1 in Vero cells. ^[2] Vidarabine acts directly on the DNA polymerase of varicella-zoster virus (VZV) and double-strand DNA viruses, including human adenoviruses. Vidarabine specifically inhibits adenovirus type 11 replication without obvious cytotoxicity in vitro. Vidarabine acts less on the synthesis of early proteins but rather on those after DNA replication. ^[3] Vidarabine is an antiviral drug with activity against herpes viruses, poxviruses, and certain rhabdoviruses, hepadnarviruses, and RNA tumor viruses. Vidarabine also is active against vaccinia virus both in vitro and in vivo. ^[4]
in vivo	Vidarabine is rapidly deaminated to 9-β-D-arabinofuranosyl hypoxanthine (Ara-Hx) as the principal metabolite. ^[3]

プロトコル(参考用のみ)

参考

[4] Shen W, et al. Bioorg Med Chem Lett, 2009, 19(3), 792-796.

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation. [ Neuron, 2017, 96(6):1290-1302]	PubMed: 29268096
Rational Design of a Profluorescent Substrate for S-adenosylhomocysteine Hydrolase and its Applications in Bioimaging and Inhibitor Screening. [ ACS Appl Mater Interfaces, 2016, 8(39):25818-25824]	PubMed: 27626909
Repurposing FDA-approved drugs for anti-aging therapies. [ Biogerontology, 2016, 17(5-6):907-920]	PubMed: 27484416

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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