Xylazine HCl

製品コードS2516 バッチS251601

化学情報

	Synonyms	BAY 1470 hydrochloride	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₁₂H₁₆N₂S.HCl
	分子量	256.79	CAS No.	23076-35-9
Solubility (25°C)*	体外	DMSO	44 mg/mL (171.34 mM)
		Ethanol	44 mg/mL (171.34 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Xylazine(BAY 1470 hydrochloride) is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.
in vivo	Xylazine dose-dependently inhibits norepinephrine release and lipolysis in beagle dogs. Xylazine also tends to decrease epinephrine levels dose-dependently. ^[1] Xylazine hydrochloride dose- and time-dependently reduces amount of minimum alveolar concentration (MAC) in horse. Xylazine hydrochloride dose- and time-dependently increases blood glucose concentration in horse. ^[2] Xylazine induces variable bilateral caudal analgesia extending from coccyx to S3, with minimal sedation, ataxia, and cardiovascular and respiratory depression in standing mares. Xylazine significantly decreases heart and respiratory rates, systolic, diastolic, and mean arterial blood pressure, PCV, hemoglobin concentration, arterial oxygen content, and oxygen transport. ^[3] Xylazine results in significantly decreased heart rate, increased incidence of atrioventricular block, and decreased cardiac output and cardiac index in horse. ^[4] Xylazine induces sedation and selective (S3 to Co) analgesia for at least 2 hours in cows. Xylazine significantly decreases heart rate, respiratory rate, rate of ruminal contractions, arterial blood pressure, PaO2, PCV, and total solids concentration, and significantly increases PaCO2, base excess, and bicarbonate concentration in cows. ^[5] Xylazine severely depresses the N3 field (-75%) and completely abolishes the climbing fiber field (-100%) in the nonanesthetized, decerebrated rat. Xylazine- ketamine injections also severely depresses the N3 field (-75%) and nearly completely abolishes theclimbing fiber field (-90%) in the nonanesthetized, decerebrated rat.^[6]

製品説明

Xylazine(BAY 1470 hydrochloride) is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.

in vivo

Xylazine dose-dependently inhibits norepinephrine release and lipolysis in beagle dogs. Xylazine also tends to decrease epinephrine levels dose-dependently. ^[1] Xylazine hydrochloride dose- and time-dependently reduces amount of minimum alveolar concentration (MAC) in horse. Xylazine hydrochloride dose- and time-dependently increases blood glucose concentration in horse. ^[2] Xylazine induces variable bilateral caudal analgesia extending from coccyx to S3, with minimal sedation, ataxia, and cardiovascular and respiratory depression in standing mares. Xylazine significantly decreases heart and respiratory rates, systolic, diastolic, and mean arterial blood pressure, PCV, hemoglobin concentration, arterial oxygen content, and oxygen transport. ^[3] Xylazine results in significantly decreased heart rate, increased incidence of atrioventricular block, and decreased cardiac output and cardiac index in horse. ^[4] Xylazine induces sedation and selective (S3 to Co) analgesia for at least 2 hours in cows. Xylazine significantly decreases heart rate, respiratory rate, rate of ruminal contractions, arterial blood pressure, PaO2, PCV, and total solids concentration, and significantly increases PaCO2, base excess, and bicarbonate concentration in cows. ^[5] Xylazine severely depresses the N3 field (-75%) and completely abolishes the climbing fiber field (-100%) in the nonanesthetized, decerebrated rat. Xylazine- ketamine injections also severely depresses the N3 field (-75%) and nearly completely abolishes theclimbing fiber field (-90%) in the nonanesthetized, decerebrated rat.^[6]

プロトコル(参考用のみ)

参考

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人間や獣医の診断であるか治療的な使用のためにでない。

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