ZLN005

製品コードS7447 バッチS744701

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₇H₁₈N₂

分子量

250.34

CAS No.

49671-76-3

Solubility (25°C)*

体外

DMSO

37 mg/mL (147.79 mM)

Ethanol

2 mg/mL (7.98 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	ZLN005は、強力で組織特異的なPGC-1α転写活性化因子です。
in vitro	In L6 myotubes, ZLN005 increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase, and improves glucose uptake and fatty acid oxidation without obvious cytotoxicity. While this compound does not have the same effects in rat primary hepatocytes, which suggests cell type–specificity.
in vivo	ZLN005 (15 mg/kg, p.o.) produces antihyperglycemia and antihyperlipidemia effects and increases insulin sensitivity in db/db mice but not lean mice.

プロトコル(参考用のみ)

動物実験	動物モデル	Male C57BKS db/db and lean littermate C57BKS mice.
	投薬量	~15 mg/kg
	投与方法	p.o.

参考

https://pubmed.ncbi.nlm.nih.gov/23250358/

カスタマーフィードバック

: Data from [Data independently produced by , , Exp Cell Res, 2016, 345(1):25-36.]

: Data from [Data independently produced by , , Endocrine, 2016, 53(2):443-52]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain [ bioRxiv, 2025, 2025.01.10.632395]	PubMed: 39868091
PPAR gamma and PGC-1alpha activators protect against diabetic nephropathy by suppressing the inflammation and NF-kappaB activation [ Nephrology (Carlton), 2024, 29(12):858-872]	PubMed: 39229715
ZLN005 improves the survival of polymicrobial sepsis by increasing the bacterial killing via inducing lysosomal acidification and biogenesis in phagocytes [ Front Immunol, 2023, 14:1089905]	PubMed: 36820088
The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptor γ coactivator-1α [ Anim Nutr, 2022, 11:121-131]	PubMed: 36204284
Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α [ Ann Transl Med, 2022, 10(22):1241]	PubMed: 36544637
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis [ Biomed Pharmacother, 2021, 144:112331]	PubMed: 34673421
PGC-1ɑ Mediated-EXOG, a Specific Repair Enzyme for Mitochondrial DNA, Plays an Essential Role in the Rotenone-Induced Neurotoxicity of PC12 Cells [ J Mol Neurosci, 2021, 10.1007/s12031-020-01775-6]	PubMed: 33515431
Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells [ Stem Cell Reports, 2020, S2213-6711(20)30418-5]	PubMed: 33186539
Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers [ Cancers (Basel), 2020, 12(9)E2397]	PubMed: 32847042
Overexpression of Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α Protects Cardiomyocytes From Lipopolysaccharide-Induced Mitochondrial Damage and Apoptosis [ Inflammation, 2020, 10.1007/s10753-020-01255-4]	PubMed: 32529514

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。