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Synonyms | Storage (From the date of receipt) |
Store at room temperature, 3 years. | ||
化学式 | C47H51NO14 |
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分子量 | 853.91(Only for Paclitaxel) | CAS No. | ||
Solubility (25°C)* | 体外 | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Nab-Paclitaxel, a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system. Solutions are unstable and should be fresh-prepared. |
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in vitro | Treating human pancreatic ductal adenocarcinoma cells first with gemcitabine followed by Nab-Paclitaxel at 48 hours is found to have the greatest inhibition of cell growth.[3] |
in vivo | In mice with human pancreatic cancer xenografts, nab-paclitaxel alone and in combination with gemcitabine deplete the desmoplastic stroma. The intratumoral concentration of gemcitabine is increased by 2.8-fold in mice receiving nab-paclitaxel plus gemcitabine versus those receiving gemcitabine alone.[4] |
細胞アッセイ | 細胞株 | Human pancreatic ductal adenocarcinoma cell lines |
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濃度 | 100 nM | |
反応時間 | 24 h | |
実験の流れ | Cells are seeded in 96-well plates at a density of 1,000–5,000 cells per well in 100 μL medium. Nab-Paclitaxel and gemcitabine are added and incubated at 37°C for 24 hours. Proliferation Is measured by the alamarBlue assay. |
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動物実験 | 動物モデル | Mice harboring PANC265 xenograft(female athymic nude mice) |
投薬量 | i.v. | |
投与方法 |
Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma [ J Transl Med, 2023, 21(1):730] | PubMed: 37848935 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。