ACSS2 inhibitor

製品コードS8588 バッチS858803

印刷

化学情報

Synonyms

Ac-CoA Synthase Inhibitor1

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₀H₁₈N₄O₂S₂

分子量

410.51

CAS No.

508186-14-9

Solubility (25°C)*

体外

DMSO (warmed with 50ºC water bath)

220 mg/mL (535.91 mM)

Ethanol

5 mg/mL (12.17 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	1.030mg/ml (2.51mM)	Taking the 1 mL working solution as an example, add 50 μL of 20.5 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	1.500mg/ml (3.65mM)	Taking the 1 mL working solution as an example, add 50 μL of 30 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV).
in vitro	This quinoxaline compound inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC50 = 6.8 μM. This chemical is also able to inhibit HepG2 utilization of [14C]acetate for histone acetylation with IC50 = 5.5 μM^[1].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	MDA-MB-231-R cells
	濃度	10 uM
	反応時間	6 h
	実験の流れ	10 µM of ACSS2 inhibitor was added in flag-WT or KR-STAT3 expressing MDA-MB-231-R cells and incubated for 6 h.
動物実験	動物モデル	Female C57BL/6J mice
	投薬量	15 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/25525877/
https://pubmed.ncbi.nlm.nih.gov/35649368/
https://pubmed.ncbi.nlm.nih.gov/34035164/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation [ Nat Commun, 2025, 16(1):2071]	PubMed: 40021646
ACSS2-TFEB axis acts as a critical regulator of the autophagic machinery in head and neck squamous cell carcinoma [ Cell Death Dis, 2025, 16(1):650]	PubMed: 40858538
High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA [ Cell Rep, 2025, 44(7):115947]	PubMed: 40616844
KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation [ Cell Rep, 2025, 44(4):115444]	PubMed: 40131933
Inhibition of ACSS2-mediated histone crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence [ Nat Commun, 2024, 15(1):3200]	PubMed: 38615014
Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ-TPH2 Axis [ Research (Wash D C), 2024, 7:0400]	PubMed: 38939042
Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway [ Cell Commun Signal, 2024, 22(1):187]	PubMed: 38515158
Sodium benzoate induces pancreatic inflammation and β cell apoptosis partially via benzoylation [ Ecotoxicol Environ Saf, 2024, 270:115877]	PubMed: 38150747
Metabolic control of luteinizing hormone-responsive ovarian steroidogenesis [ J Biol Chem, 2024, 301(1):108042]	PubMed: 39615688
Role of ATP citrate lyase and its complementary partner on fatty acid synthesis in gastric cancer [ Sci Rep, 2024, 14(1):30043]	PubMed: 39627427

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。