Ademetionine

製品コードS5109 バッチS510901

化学情報

	Synonyms	AdoMet, S-Adenosylmethionine, SAMe	Storage (From the date of receipt)	3 years -20°C powder (seal)
	化学式	C₁₅H₂₂N₆O₅S
	分子量	398.44	CAS No.	29908-03-0
Solubility (25°C)*	体外	DMSO	79 mg/mL (198.27 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.
in vitro	Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA^[1].
in vivo	SAMe is able to cross the intestinal wall and increase plasma levels. Studies in rats reveal that absorption of the drug is much better after intraduodenal administration compared to oral administration. The systemic bioavailability after oral SAMe administration appears to be low. SAMe dose-dependently (12.5, 25, 50, 100 and 200 mg/kg sc.) decreases immobility time in the forced swimming test in mice and rats. Chronic treatment with SAMe is associated with an increase in density of b-receptors, and a decrease in the affinity of a1 adrenoceptors for phenylephrine in rat cerebral membranes^[1].

プロトコル(参考用のみ)

参考

[1] Bottiglieri T. Expert Opin Investig Drugs. 1997, 6(4):417-26.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

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The Roles of Imprinted SLC22A18 and SLC22A18AS Gene Overexpression Caused by Promoter CpG Island Hypomethylation as Diagnostic and Prognostic Biomarkers for Non-Small Cell Lung Cancer Patients [ Cancers (Basel), 2020, 12(8):E2075]	PubMed: 32726996

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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