Allicin

製品コードS3860 バッチS386004

印刷

化学情報

Chemical Structure Synonyms diallyl thiosulfinate Storage
(From the date of receipt)		 2 years  -20°C  liquid
化学式

C6H10OS2
分子量 162.27 CAS No. 539-86-6
Solubility (25°C)* 体外 DMSO 32 mg/mL (197.2 mM)
Ethanol 32 mg/mL (197.2 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 すりおろしたてのニンニク抽出物の主要な生物活性成分であるAllicin（ジアリルチオスルフィネート）は、抗菌作用、抗真菌作用、抗寄生虫作用など、さまざまな生物活性を持っています。
in vitro Allicin is readily permeable through phospholipid membranes aiding its biological activity. It inhibits the growth of cancer cells of murine and human origin. This compound induces the formation of apoptotic bodies, nuclear condensation and a typical DNA ladder in cancer cells. Furthermore, activation of caspases-3, -8 and -9 and cleavage of poly(ADP-ribose) polymerase are induced by this chemical. It is highly reactive with thiol-groups but under certain conditions it also reacts with itself forming further compounds which can also be bioactive, such as vinyl-dithiins, ajoene and polysulfanes. Since this substance is able to oxidize biomolecules such as glutathione or protein cysteine residues under physiological conditions, it fulfils the definition of a Reactive Sulfur Species (RSS). It certainly acts as a “physiological antioxidant” by inducing the cellular “phase II detoxification system”. This agent activates the redox-dependent mammalian transcription factor Nrf-2 the localization of which depends upon the Keap1 protein (Kelch-like ECH1-associated protein), presumably by oxidizing the regulatory cysteine-residues, as demonstrated for the YAP1-transcription factor which is a functional homologue of the Nrf-2 system in yeast. In vitro studies show that it inhibits TNF-α-mediated T cell adhesion to extracellular matrix components and to endothelial cells. It also inhibits TNF-α-mediated intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression on human vascular endothelial cells.
in vivo Allicin has a protective effect on immune-mediated, Con A-induced hepatitis in mice.
密度 1.109 g/mL

プロトコル(参考用のみ)

細胞アッセイ 細胞株 L-929, SW480 and HeLa cells
濃度 0-100 μM
反応時間 24 or 48 h
実験の流れ Cell viability assays are carried out as described with slight modifications. Briefly, cells are seeded at a density of 3×104 cells/well into 24-well plates. After 24 h, this compound is added to the medium at various concentrations and incubated for 24 or 48 h as indicated. At the end of the incubation, 50 μl of MTT (2 mg/ml) per well is added, and the formazan crystals formed are solubilized in acidified isopropanol after aspirating the medium. The extent of MTT reduction is measured spectrophotometrically at 570 nm, and the cell survival is expressed as percentage over the untreated control.
動物実験 動物モデル Balb/c male mice
投薬量 8-20 mg/kg/day
投与方法 by oral gavage

参考

  • https://pubmed.ncbi.nlm.nih.gov/14757128/
  • https://pubmed.ncbi.nlm.nih.gov/28035949/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Antiferroptotic properties of allicin and related organosulfur compounds-diallyl disulfide and diallyl trisulfide-from Garlic [ Food Chem Toxicol, 2025, 195:115124] PubMed: 39580015
Role of miR-455-3p in the alleviation of LPS-induced acute lung injury by allicin [ Heliyon, 2024, 10(20):e39338] PubMed: 39502213

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。