Alpha-Mangostin

製品コードS3804 バッチS380401

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C24H26O6
分子量 410.46 CAS No. 6147-11-1
Solubility (25°C)* 体外 DMSO 82 mg/mL (199.77 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.
in vitro α-mangostin shows both fast-binding and slow-binding inhibitions to FAS in vitro. It inhibits FAS overall reaction with a half-inhibitory concentration (IC50) value of 5.54 μM non-competitively with respect to NADPH, and partially competitively against both substrates acetyl-CoA and malonyl-CoA. α-Mangostin could reduce cell viability and induce apoptosis in human breast cancer cells[1]. Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM H2O2-induced apoptosis of RPE cells. Alpha-mangostin can activate the expression of PKC-δ and down-regulate the expression of mitogen-activated protein kinases (MAPKs), including ERK1/2, JNK, P38[2].
in vivo Alpha-mangostin stimulation results in an increase of superoxide dismutase (SOD) activity, glutathione peroxidase (GPX) activity and glutathione (GSH) content both in vivo and vitro. It suppresses light-induced retina dysfunction. Alpha-mangostin has protective effect on kidney, heart and brain tissues against oxidative stress[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 human breast cancer MCF-7 and MDA-MB-231 cells
濃度 0, 1, 2, 3, 4, 6, 8, and 10 μM
反応時間 24 h and 48 h
実験の流れ MCF-7 and MDA-MB-231 cells are treated with 0, 1, 2, 3, 4, 6, 8, and 10 μM α-mangostin for 24 h and 48 h. Cell viability is then determined by the CCK-8 assay.
動物実験 動物モデル Female balb/c mice, aged 8 weeks
投薬量 10 mg/kg (lower-dose) or 30 mg/kg body weight (higher-dose)
投与方法 intragastric administration

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback [ Front Pharmacol, 2021, 12:692806] PubMed: 34305602

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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