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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C24H26O6 |
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分子量 | 410.46 | CAS No. | 6147-11-1 | |
Solubility (25°C)* | 体外 | DMSO | 82 mg/mL (199.77 mM) | |
Ethanol | 82 mg/mL (199.77 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING. |
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in vitro | α-mangostin shows both fast-binding and slow-binding inhibitions to FAS in vitro. It inhibits FAS overall reaction with a half-inhibitory concentration (IC50) value of 5.54 μM non-competitively with respect to NADPH, and partially competitively against both substrates acetyl-CoA and malonyl-CoA. α-Mangostin could reduce cell viability and induce apoptosis in human breast cancer cells[1]. Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM H2O2-induced apoptosis of RPE cells. Alpha-mangostin can activate the expression of PKC-δ and down-regulate the expression of mitogen-activated protein kinases (MAPKs), including ERK1/2, JNK, P38[2]. |
in vivo | Alpha-mangostin stimulation results in an increase of superoxide dismutase (SOD) activity, glutathione peroxidase (GPX) activity and glutathione (GSH) content both in vivo and vitro. It suppresses light-induced retina dysfunction. Alpha-mangostin has protective effect on kidney, heart and brain tissues against oxidative stress[2]. |
細胞アッセイ | 細胞株 | human breast cancer MCF-7 and MDA-MB-231 cells |
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濃度 | 0, 1, 2, 3, 4, 6, 8, and 10 μM | |
反応時間 | 24 h and 48 h | |
実験の流れ | MCF-7 and MDA-MB-231 cells are treated with 0, 1, 2, 3, 4, 6, 8, and 10 μM α-mangostin for 24 h and 48 h. Cell viability is then determined by the CCK-8 assay. | |
動物実験 | 動物モデル | Female balb/c mice, aged 8 weeks |
投薬量 | 10 mg/kg (lower-dose) or 30 mg/kg body weight (higher-dose) | |
投与方法 | intragastric administration |
α-Mangostin Alleviated Inflammation in Rats With Adjuvant-Induced Arthritis by Disrupting Adipocytes-Mediated Metabolism-Immune Feedback [ Front Pharmacol, 2021, 12:692806] | PubMed: 34305602 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。