Alverine Citrate

製品コードS3054 バッチS305401

化学情報

	Synonyms	NSC 35459	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₀H₂₇N.C₆H₈O₇
	分子量	473.56	CAS No.	5560-59-8
Solubility (25°C)*	体外	DMSO	95 mg/mL (200.6 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders.
in vitro	In pharmacological studies, alverine citrate has been shown to exert an effect on intestinal motility and intestinal sensitivity, two factors recognized as involved in the onset of FBD, without exhibiting the potential drawbacks of a medication with systemic effects.Alverine citrate affects basal and stimulated motility via a calcium-dependent and -independent inhibition of neuronal excitability as well as direct inactivation of L-type Ca2+ of smooth muscle cells. Experimental findings support an antinociceptive action by selective receptor-mediated mechanisms.

製品説明

Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders.

in vitro

In pharmacological studies, alverine citrate has been shown to exert an effect on intestinal motility and intestinal sensitivity, two factors recognized as involved in the onset of FBD, without exhibiting the potential drawbacks of a medication with systemic effects.Alverine citrate affects basal and stimulated motility via a calcium-dependent and -independent inhibition of neuronal excitability as well as direct inactivation of L-type Ca2+ of smooth muscle cells. Experimental findings support an antinociceptive action by selective receptor-mediated mechanisms.

プロトコル(参考用のみ)

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity. [ Am J Physiol Lung Cell Mol Physiol, 2018, 315(2):L133-L148]	PubMed: 29631359

The vagal ganglia transcriptome identifies candidate therapeutics for airway hyperreactivity. [ Am J Physiol Lung Cell Mol Physiol, 2018, 315(2):L133-L148]

PubMed: 29631359

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。