Sodium 4-Aminosalicylate

製品コードS4073 バッチS407301

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C7H7NO3.2H2O.Na
分子量 211.15 CAS No. 6018-19-5
Solubility (25°C)* 体外 DMSO 42 mg/mL (198.91 mM)
Water 42 mg/mL (198.91 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.
in vitro 4-Aminosalicylate reacts promptly with DPPH, suggesting a potent radical scavenger activity. 4-Aminosalicylate exhibits peroxyl radical scavenging activity generated by the water-soluble 2,2'-azobis-(2-amidinopropane hydrochloride) azoinitiator of peroxyl radicals, as evidenced by the inhibition of cis-parinaric acid fluorescence decay or oxygen consumption. 4-Aminosalicylate rapidly scavenges peroxyl radicals in the aqueous phase, producing a concentration-dependent inhibition period similar to Trolox or cysteine, suggesting an antioxidant activity of chain-breaking type. [1] [14C]4-Aminosalicylate transforms to a number of metabolites, among which we have characterized salicylate and gentisate, in activated mononuclear cells and activated granulocytes. 4-Aminosalicylate (0.65 mM) diminishes the lethal effect on cultured Chinese hamster ovary cells of adding either superoxide radical or hydrogen peroxide. [2] Aminosalicylate (25 mM) stimulates phospholipase D in a time- and concentration-dependent manner via a pathway involving inositol 1,4,5-trisphosphate generation, calcium fluxes, and Gi/Go in cultured mouse peritoneal macrophages. 4-aminosalicylate (20 mM) increases the levels of inositol 1,4,5-trisphosphate by 260% after treatment of macrophages. 4-aminosalicylate (5 mM) potentiates the activation of PLD by protein kinase C in cultured mouse peritoneal macrophages. [3] 4-aminosalicylate (0.1 mM) decreases the LTB4 synthesis in a dose-related fashion in isolated colonic mucosal cells, thus diminishes the LTB4/PGE2 ratio. [4] 4-aminosalicylate (0.1 mg/mL) is preferentially transported in the basolateral (BL) to apical (AP) direction, and the N-acetyl metabolite appeared only in the AP compartment. [5]
in vivo 4-aminosalicylate (7.5 mg/mL, regional perfusions) results in the appearance of N-acetyl-5-aminosalicylic acid in the intestinal lumen in the anesthetized rat. [5]
特徴 4-Aminosalicylate is considered to be the active moiety of sulfasalazine.

プロトコル(参考用のみ)

カスタマーフィードバック

Data from [Data independently produced by , , PLoS One, 2016, 11(3):e0149754.]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Silibinin inhibits in vitro ketosis by regulating HMGCS2 and NF-kB: elucidation of signaling molecule relationship under ketotic conditions [ In Vitro Cell Dev Biol Anim, 2019, 55(5):368-375] PubMed: 31025252
Atg7 Knockdown Augments Concanavalin A-Induced Acute Hepatitis through an ROS-Mediated p38/MAPK Pathway. [Zhuang Y, et al. PLoS One, 2016, 11(3):e0149754] PubMed: 26939081

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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