Amitraz

製品コードS3643 バッチS364301

印刷

化学情報

Synonyms

NSC 324552

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₉H₂₃N₃

分子量

293.41

CAS No.

33089-61-1

Solubility (25°C)*

体外

DMSO

58 mg/mL (197.67 mM)

Ethanol

58 mg/mL (197.67 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Amitraz (NSC 324552)は、トリアザペンタジエンであり、α2アドレナリン受容体作動薬であり、アミジン系化学物質ファミリーの一員です。非全身性殺ダニ剤および殺虫剤です。
in vitro	Amitraz was not cytotoxic to human luteinized granulosa cells at concentrations of 1, 10 or 50 µg/ml for exposures of 2-72 h While the highest concentration of this compound tested, 100 µg/ml, caused significant cell death after exposures of 24, 48 and 72 h. It decreased the amount of progesterone produced by each cell after a 4 h exposure; the reduction in progesterone concentration was not caused by decreased cell viability.
in vivo	Amitraz is an α2-adrenergic receptor (α2-AR) agonist that adversely affects the mammalian reproductive system by binding to presynaptic α2-AR in the hypothalamus, thus inhibiting noradrenalin release and decreasing GnRH secretion. When 30 mg/kg of this compound was administered to rats, the ovulatory LH surge was prevented. It inhibited insulin but stimulated glucagon secretion in a perfused rat pancreas model. This chemical also decreased intestinal motility, and inhibited prostaglandin synthesis by bovine seminal vesicle microsomes. It can be absorbed through the skin and can exert systemic effects via the vascular system in humans. Low doses of AMZ (l-25 mg/kg) decreased motor activity and altered the rates and patterns of responding under schedule-controlled conditions. Intermediate doses (50-100 mg/kg) affect visual-evoked potentials and lower body weight and temperature. In addition, 100 mg/kg produces slight MAO inhibition and characteristic signs of intoxication (e.g., weight loss and hyperreactivity). High doses (>lOO mg/kg) produce more pronounced MAO inhibition, extreme weight loss and hyperreactivity, aggression, and lethality.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Luteinized human granulosa cells
	濃度	1, 10, 50 and 100 µg/ml
	反応時間	2, 4, 6, 24, 48 or 72 h
	実験の流れ	Cells were exposed to 1, 10, 50 and 100 µg/ml amitraz for 2, 4, 6, 24, 48 or 72 h.
動物実験	動物モデル	Adult male Long-Evans hooded rats
	投薬量	1-200 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/16085667/
https://pubmed.ncbi.nlm.nih.gov/2925011/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。