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Synonyms | Amoxycillin | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C16H19N3O5S |
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分子量 | 365.4 | CAS No. | 26787-78-0 | |
Solubility (25°C)* | 体外 | DMSO | 73 mg/mL (199.78 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. |
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in vitro | Amoxicillin treated cells secrete high amounts of interleukin-5 and mostly lower or no amounts of tumor necrosis factor alpha, interleukin-4, and interferon-gamma. Amoxicillin-specific T cell clones fails to show drug-specific cytotoxicity, but killed target cells in the presence of concanavalin A, indicating a principal ability to be cytolytic. [1] Amoxicillin releases faster in pH 1.0 hydrochloric acid (HCl) than in pH 7.8 phosphate buffer. Amoxicillin would be degraded to some extent in a pH 1.0 HCl medium at 37 degrees C, which indicated that amoxicillin is not stable in an acidic surrounding. [2] Amoxicillin inhibits 4 of 15 isolates at 8 mg/mL or less but is not bactericidal against any of the isolates at that concentration. Amoxicillin in combination with clavulanic acid is bactericidal for 14 of 15 isolates tested at an amoxicillin concentration of 4 mg/mL or less and a clavulanic acid concentration of 2 mg/mL or less. [3] Amoxicillin inhibits 50% of isolates tested decreased from 0.5 mg/mL (range, 0.25 to 1 mg/mL) to 0.06 mg/mL (range, 0.01 to 0.25 mg/mL) in the presence of only 4 mg of cefotaxime per mL. [4] |
Stability of 10 Beta-Lactam Antibiotics in Human Plasma at Different Storage Conditions [ Ther Drug Monit, 2023, 10.1097/FTD.0000000000001100] | PubMed: 37199408 |
High-throughput analysis for the simultaneous quantification of nine beta-lactam antibiotics in human plasma by UPC2-MS/MS: Method development, validation, and clinical application [ J Pharm Biomed Anal, 2022, 219:114904] | PubMed: 35772234 |
Desorption Electrospray Ionization Mass Spectrometry Assay for Label-Free Characterization of SULT2B1b Enzyme Kinetics [ ChemMedChem, 2022, e202200043] | PubMed: 35080134 |
A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro [ PLoS Comput Biol, 2020, 16(12):e1008489] | PubMed: 33382685 |
Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types. [Doherty KR, et al. Toxicol Appl Pharmacol, 2015, 285(1):51-60] | PubMed: 25841593 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。