Ampicillin Trihydrate

製品コードS4148 バッチS414801

印刷

化学情報

Chemical Structure Synonyms NCI-C56086,D-(-)-α-Aminobenzylpenicillin trihydrate Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C16H19N3O4S.3H2O
分子量 403.45 CAS No. 7177-48-2
Solubility (25°C)* 体外 DMSO 81 mg/mL (200.76 mM)
Water 2 mg/mL (4.95 mM)
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Ampicillin Trihydrate (NCI-C56086、D-(-)-α-アミノベンジルペニシリン三水和物) は、細菌の細胞膜内表面にあるトランスペプチダーゼを不活性化することにより、細菌の細胞壁合成 (ペプチドグリカン架橋) を阻害するβ-ラクタム系抗生物質です。
in vitro

Ampicillin Trihydrate (500 mg) results in rapid bactericidal effect for SP34, the concentrations declines to the limit of detection (100 CFU/mL) during the initial 6 hours, and regrowth is not observed over the remaining 18 hours.

in vivo

Ampicillin Trihydrate (10 mg/kg) results in half life (t 1/2) of 1.2 hours in goats and 2.48 hours in sheep, clearance (Cl) of 2921 mL/h·kg in goats and 262 mL/h·kg in sheep, ampicillin volume of distribution (Vdarea) of 5673 mL/kg in goats and 992 mL/kg in sheep. This compound (0.18 kg/kg-3 kg/kg) results in no dose-related mortality, normal body weights, no compound-related gross or histopathologic lesions and diarrhea in mice and rats. Ampicillin in combination of norfloxacin, at a dose of 1g/L, maximally suppresses the numbers of cecal aerobic and anaerobic bacteria in ob/ob mice. This chemical in combination of norfloxacin results in a significant improvement in fasting glycemia and oral glucose tolerance reduced liver triglycerides and increased liver glycogen and concomitant reduction of plasma lipopolysaccharides in ob/ob mice. This compound (20 mg/kg) treats five foals, the mean peak serum ampicillin concentration at two to three days old is 5.0 μg/mL at 1 hours after treatment, the mean peak serum concentration at 16 days to 21 days old is 2.7 μg/mL at 2 hours, the concentrations steadily declines and ampicillin is not detected in the serum from any of the foals by 24 hours, and serum clearance averages 17.7 mL/min/kg at two to three days and 35.8 mL/min/kg at 16 days to 21 days.

特徴 More effective than levofloxacin and ciprofloxacin against Streptococcus pneumoniae.

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/10049286/
  • https://pubmed.ncbi.nlm.nih.gov/9280365/
  • https://pubmed.ncbi.nlm.nih.gov/2499954/
  • https://pubmed.ncbi.nlm.nih.gov/18326786/
  • https://pubmed.ncbi.nlm.nih.gov/6479137/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry [ ACS Infect Dis, 2024, 10(12):4087-4102] PubMed: 39566904
Feasibility analysis and study of an intrahepatic portal vein infection hepatic alveolar echinococcosis C57 mouse model [ Front Vet Sci, 2022, 9:994652] PubMed: 36590810
Intestinal Methicillin-Resistant Staphylococcus aureus Causes Prosthetic Infection via 'Trojan Horse' Mechanism: Evidence From a Rat Model [ Bone Joint Res, 2020, 16;9(4):152-161] PubMed: 32431806

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。