Anacardic Acid

製品コードS7582 バッチS758202

印刷

化学情報

Chemical Structure Synonyms 6-pentadecylsalicylic Acid Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C22H36O3
分子量 348.52 CAS No. 16611-84-0
Solubility (25°C)* 体外 DMSO 69 mg/mL (197.98 mM)
Ethanol (warmed with 50ºC water bath) 69 mg/mL (197.98 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.
in vitro Anacardic acid is found to be a common inhibitor of several clinically targeted enzymes such as NFkB kinase, histone acetyltransferase (HATs), lipoxygenase (LOX-1), xanthine oxidase, tyrosinase and ureases[4]. Anacardic acid is also an efficient inhibitor of Tip60 in vitro.It inhibits the Tip60-dependent acetylation and activation of the ATM protein kinase in HeLa cells, and sensitizes the cells to the cytotoxic effects of radiation[2]. Anacardic acid can effectively prevent cell damage induced by H2O2 because this can be converted to ROS, hydroxyl radicals, in the presence of metal ions[4].
in vivo Anacardic acid attenuates over-expression of Gata4, α-MHC and cTnT in fetal mouse hearts exposed to ethanol. Anacardic acid inhibits binding of P300, PCAF to the promoter of Gata4[3].

プロトコル(参考用のみ)

キナーゼアッセイ HAT and HDAC Activity Assays
After homogenization of cardiac tissues, nucleoproteins are extracted using a Nuclear Extract Kit according to the manufacturer's instructions. HAT and HDAC activities of the nuclear protein extracts are determined using a colorimetric assay included in the HAT and HDAC assay kits.
細胞アッセイ 細胞株 HeLa and 293T cells, SQ20B and SCC35 squamous cell carcinoma cell lines
濃度 0-100 μM
反応時間 40 min
実験の流れ HeLa and 293T cells are grown in Dulbecco’s modified Eagle’s medium/10% fetal calf serum. SQ20B and SCC35 squamous cell carcinoma cell lines are cultured in modified eagles medium/10% fetal calf serum.For anacardic acid (EMD Biosciences, CA) exposure, cells are preincubated with anacardic acid for 40 min, irradiated, then allowed to recover for 4 h. Cells are then switched to fresh media and allowed to grow for 10 days.
動物実験 動物モデル 9 to 11 week old Kunming mice
投薬量 0, 1.25, 2.5, 5, 10 mg/kg
投与方法 i.p.

参考

  • https://pubmed.ncbi.nlm.nih.gov/12624111/
  • https://pubmed.ncbi.nlm.nih.gov/16844118/
  • https://pubmed.ncbi.nlm.nih.gov/25101666/
  • https://pubmed.ncbi.nlm.nih.gov/22103711/

カスタマーフィードバック

Data from [Data independently produced by , , Front Immunol, 2017, 7:696]

Data from [Data independently produced by , , Oncol Rep, 2017, 38(1):229-236]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity [ Sci Adv, 2025, 11(9):eadq2881] PubMed: 40009679
PTBP1 crotonylation promotes colorectal cancer progression through alternative splicing-mediated upregulation of the PKM2 gene [ J Transl Med, 2024, 22(1):995] PubMed: 39497094
Fluoride Alters Gene Expression via Histone H3K27 Acetylation in Ameloblast-like LS8 Cells [ Int J Mol Sci, 2024, 25(17)9600] PubMed: 39273544
DNAJC12 downregulation induces neuroblastoma progression via increased histone H4K5 lactylation [ J Mol Cell Biol, 2024, mjae056] PubMed: 39716470
The mechanics of local niches in the primary tumor regulate breast cancer brain metastasis [ POLYU ELECTRONIC THESES, 2023, viii, 164] PubMed: None
HBV covalently closed circular DNA minichromosomes in distinct epigenetic transcriptional states differ in their vulnerability to damage [ Hepatology, 2021, 10.1002/hep.32245] PubMed: 34779008
HBV covalently closed circular DNA minichromosomes in distinct epigenetic transcriptional states differ in their vulnerability to damage [ Hepatology, 2021, 10.1002/hep.32245] PubMed: 34779008
Caspase-8 Regulates the Antimyeloma Activity of Bortezomib and Lenalidomide [ J Pharmacol Exp Ther, 2021, 379(3):303-309] PubMed: 34588172
Anacardic acid induces IL-33 and promotes remyelination in CNS [ Proc Natl Acad Sci U S A, 2020, 202006566] PubMed: 32817520
Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells Through Destabilizing AKT [ Int J Biol Sci, 2020, 25;16(11):1774-1784] PubMed: 32398948

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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