Anti-mouse CD8α-InVivo

製品コード：A2102 Batch: A210229

Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).

製品説明

Formulation	PBS buffer, pH 7.0
Clone	2.43
Immunogen	Mouse CTL clone L3
Isotype	Rat IgG2b, κ
Application	In vivo CD8+ T cell depletion,WB
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping	Shipped under low temperature conditions
Sterility	0.2 μM filtered
Purity	99%
Protein concentration	11.59 mg/ml
Endotoxin Level	＜1EU/mg

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Senescent SPP1+ macrophages remodel the tumor microenvironment and promote the progression of early-stage lung adenocarcinoma featured with mixed ground glass nodule [ Mol Cancer, 2025, 24(1):298]	PubMed: 41310768
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation [ Cell Discov, 2025, 11(1):84]	PubMed: 41162356
TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice [ Mil Med Res, 2025, 12(1):78]	PubMed: 41214839
Silencing PCSK9 reshapes the spatiotemporal activation of STING for safe and effective cancer immunotherapy [ Nat Commun, 2025, 10.1038/s41467-025-66630-x]	PubMed: 41290746
Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity [ Nat Commun, 2025, 16(1):3546]	PubMed: 40229277
BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma [ Cell Rep Med, 2025, 6(3):101995]	PubMed: 40107246
Nuclear glycine decarboxylase suppresses STAT1-dependent MHC-I and promotes cancer immune evasion [ EMBO J, 2025, 10.1038/s44318-025-00557-3]	PubMed: 40926122
Radiation-induced upregulation of itaconate in macrophages promotes the radioresistance of non-small cell lung cancer by stabilizing NRF2 protein and suppressing immune response [ Redox Biol, 2025, 85:103711]	PubMed: 40482348
Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway [ J Immunother Cancer, 2025, 13(2)e010252]	PubMed: 39915005
Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer [ J Immunother Cancer, 2025, 13(7)e011948]	PubMed: 40664447

人間や獣医の診断であるか治療的な使用のためにでない。