Anti-mouse CD8α-InVivo

製品コード：A2102 Batch: A210230

Anti-mouse CD8α (Clone:2.43)reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).

製品説明

Formulation	PBS buffer, pH 7.0
Clone	2.43
Immunogen	Mouse CTL clone L3
Isotype	Rat IgG2b, κ
Application	In vivo CD8+ T cell depletion,WB
Source	CHO
Storage (From the date of receipt)	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
Shipping	Shipped under low temperature conditions
Sterility	0.2 μM filtered
Purity	99%
Protein concentration	4.16 mg/ml
Endotoxin Level	＜1EU/mg

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

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Impact of gut microbiome on radiotherapy and immunotherapy efficacy in microsatellite-stable colorectal cancer: role of propionic acid and B. fragilis [ British Journal of Cancer, October 2025, 956-969]	PubMed: 40715695
Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell [ Gut Microbes, December 2023, 2249143]	PubMed: 37635362
Senescent SPP1+ macrophages remodel the tumor microenvironment and promote the progression of early-stage lung adenocarcinoma featured with mixed ground glass nodule [ Mol Cancer, 2025, 24(1):298]	PubMed: 41310768
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation [ Cell Discov, 2025, 11(1):84]	PubMed: 41162356
TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice [ Mil Med Res, 2025, 12(1):78]	PubMed: 41214839
Silencing PCSK9 reshapes the spatiotemporal activation of STING for safe and effective cancer immunotherapy [ Nat Commun, 2025, 10.1038/s41467-025-66630-x]	PubMed: 41290746
Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity [ Nat Commun, 2025, 16(1):3546]	PubMed: 40229277
BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanoma [ Cell Rep Med, 2025, 6(3):101995]	PubMed: 40107246
Nuclear glycine decarboxylase suppresses STAT1-dependent MHC-I and promotes cancer immune evasion [ EMBO J, 2025, 10.1038/s44318-025-00557-3]	PubMed: 40926122

人間や獣医の診断であるか治療的な使用のためにでない。