Apocynin

製品コードS2425 バッチS242506

印刷

化学情報

Chemical Structure Synonyms NSC 2146, Acetovanillone, NSC 209524 Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C9H10O3
分子量 166.17 CAS No. 498-02-2
Solubility (25°C)* 体外 DMSO 33 mg/mL (198.59 mM)
Ethanol 33 mg/mL (198.59 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Apocynin は、IC50 が 10 μM の選択的 NADPH オキシダーゼ阻害剤です。
in vitro Apocynin is a naturally occurring methoxy-substituted catechol used as an inhibitor of NADPH-oxidase. This compound prevents serine phosphorylation of p47phox and blocks its association with gp91phox, thus blunting NADPH oxidase activation. It can decrease the production of superoxide (O(2)(-)) from activated neutrophils and macrophages. This chemical, after metabolic conversion, inhibits the assembly of NADPH-oxidase that is responsible for reactive oxygen species (ROS) production.
in vivo Apocynin has anti-inflammatory activity in a variety of cell and animal models of inflammation. This compound attenuates the TNF-α and IL-1β production and iNOS expression in the lung of carrageenan-treated mice. It exerts beneficial effects in a mice model of spinal cord injury. This chemical reduces (1) the degree of spinal cord damage, (2) neutrophils infiltration, (3) ICAM-1 and P-selectin expression, (4) PAR and nitrotyrosine formation, (5) IκB-α degradation, (6) NF-κB activation, (7) pro-inflammatory cytokines production (TNF-α and IL-1β), (8) apoptosis (TUNEL staining, FAS ligand expression, Bax and Bcl-2 expression) and (9) MAPK activation (P-38 and phospho-JNK). LD50: Mice 9g/kg (i.g.).

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/8018341/
  • https://pubmed.ncbi.nlm.nih.gov/2160411/
  • https://pubmed.ncbi.nlm.nih.gov/19096513/
  • https://pubmed.ncbi.nlm.nih.gov/21147071/
  • https://pubmed.ncbi.nlm.nih.gov/20954833/

カスタマーフィードバック

, , Int J Endocrinol, 2016, 2016:8354745.

Data from [Data independently produced by , , Acta Biomater, 2018, 73:470-487]

Data from [Data independently produced by , , Oxid Med Cell Longev, 2017, 2017:9738745]

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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