Astilbin

製品コードS3932 バッチS393202

印刷

化学情報

Synonyms

Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside, Taxifolin 3-rhamnoside

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₁H₂₂O₁₁

分子量

450.39

CAS No.

29838-67-3

Solubility (25°C)*

体外

DMSO

90 mg/mL (199.82 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Smilax glabra Roxbの根茎から単離されたフラボノイド化合物であるAstilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside)は、抗がん作用、抗酸化作用、抗炎症作用、免疫抑制作用を示します。
in vitro	In vitro, astilbin inhibits Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibits Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions. This compound has been reported to possess multiple clinically relevant bioactivities, including antioxidant, anti-inflammatory, anti-arthritic, and anti-diabetic nephropathy properties. Nevertheless, the molecular mechanisms by which this chemical interacts with inflammatory processes are poorly understood. It not only inhibits T lymphocyte function in acute heart allograft rejection, but also inhibits migration and antigen presenting of dendritic cells (DCs).
in vivo	Astilbin is reported to reduce activation of both T and B cells in lupus-prone mice. It significantly inhibits inflammatory responses and keratinocyte over-proliferation in a mouse model of imiquimod (IMQ)-induced psoriasis. This compound undergoes extensive biotransformation specifically due to enzyme catechol-O-methyl transferase. It gives rise to 3′-O-methylastilbin, a major metabolite of this chemical, which plays important role against the inhibition activated T lymphocytes. The pharmacokinetic parameters of this compound followed by intragastric administration astilbin (40 mg/kg): C_max=37.7±14.7 ng/mL, T_max=25.8±34.3 min, t_1/2=161.6±44.1 min.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	CD4+ T cells
	濃度	0-100 μg/ml
	反応時間	3 days
	実験の流れ	Cell viability is assessed using the Cell Counting Kit-8 (CCK8) assay at 3 days after induction of Th17 differentiation. The mean optical density (OD) of the three wells in each group is used to calculate the percentage of cell proliferation.
動物実験	動物モデル	BALB/c mice (male, 18 to 20 g, 8 week-old)
	投薬量	25 to 50 mg/kg
	投与方法	orally administered

参考

https://pubmed.ncbi.nlm.nih.gov/26784569/
https://www.hindawi.com/journals/njos/2016/7830367/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Ethanol extract from Astilbe chinensis inflorescence suppresses inflammation in macrophages and growth of oral pathogenic bacteria [ PLoS One, 2024, 19(7):e0306543]	PubMed: 38959234

Ethanol extract from Astilbe chinensis inflorescence suppresses inflammation in macrophages and growth of oral pathogenic bacteria [ PLoS One, 2024, 19(7):e0306543]

PubMed: 38959234

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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