Atorvastatin Calcium

製品コードS2077 バッチS207751

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

2(C₃₃H₃₄FN₂O₅).Ca

分子量

1155.34

CAS No.

134523-03-8

Solubility (25°C)*

体外

DMSO

100 mg/mL (86.55 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.
in vitro	Atorvastatin Calcium inhibits pre-proET-1 mRNA expression in a concentration- and time-dependent fashion (60-70% maximum inhibition) and reduces immunoreactive ET-1 levels (25-50%), this inhibitory effect is maintained in the presence of oxidized LDL (1-50 mg/mL). ^[1] This compound significantly reduces angiotensin II-induced and epidermal growth factor-induced ROS production in VSMCs. It downregulates mRNA expression of the NAD(P)H oxidase subunit nox1 in VSMCs, whereas p22phox mRNA expression is not significantly altered. The chemical inhibits membrane translocation of rac1 GTPase, which is required for the activation of NAD(P)H oxidase. ^[2] Atorvastatin (0.1 μM) significantly diminishes NF-κB activation induced by Ang II and TNF-α in mononuclear cells and VSMC. This compound (1 μM) diminishes MCP-1 expression induced by Ang II, TNF-α and is reversed by Mevalonate only in Ang II-stimulated cells. It (1 μM) diminishes IP-10 expression induced by Ang II and by TNF-α in VSMC, and this reduction is partially reversed by Mevalonate. ^[3] Atorvastatin and Gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation. ^[4]
in vivo	Atorvastatin Calcium reduces vascular mRNA expression of p22phox and nox1 and increased aortic catalase expression in statin-treated rats. ^[2] This compound inhibits the increase of hsCRP serum levels in the cholesterol-fed rabbits. It inhibits the increase in osteopontin expression throughout the valve leaflet in the hypercholesterolemic aortic valves. ^[5]

製品説明

Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.

in vitro

Atorvastatin Calcium inhibits pre-proET-1 mRNA expression in a concentration- and time-dependent fashion (60-70% maximum inhibition) and reduces immunoreactive ET-1 levels (25-50%), this inhibitory effect is maintained in the presence of oxidized LDL (1-50 mg/mL). ^[1]

This compound significantly reduces angiotensin II-induced and epidermal growth factor-induced ROS production in VSMCs. It downregulates mRNA expression of the NAD(P)H oxidase subunit nox1 in VSMCs, whereas p22phox mRNA expression is not significantly altered. The chemical inhibits membrane translocation of rac1 GTPase, which is required for the activation of NAD(P)H oxidase. ^[2]

Atorvastatin (0.1 μM) significantly diminishes NF-κB activation induced by Ang II and TNF-α in mononuclear cells and VSMC. This compound (1 μM) diminishes MCP-1 expression induced by Ang II, TNF-α and is reversed by Mevalonate only in Ang II-stimulated cells. It (1 μM) diminishes IP-10 expression induced by Ang II and by TNF-α in VSMC, and this reduction is partially reversed by Mevalonate. ^[3]

Atorvastatin and Gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation. ^[4]

in vivo

Atorvastatin Calcium reduces vascular mRNA expression of p22phox and nox1 and increased aortic catalase expression in statin-treated rats. ^[2]

This compound inhibits the increase of hsCRP serum levels in the cholesterol-fed rabbits. It inhibits the increase in osteopontin expression throughout the valve leaflet in the hypercholesterolemic aortic valves. ^[5]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	BAECs
	濃度	10 μM
	反応時間	24 h
	実験の流れ	Cells were treated with indicated concentration of the drug for 24 hour.
動物実験	動物モデル	Male New Zealand White rabbits
	投薬量	3 mg/kg
	投与方法	p.o.

参考

https://pubmed.ncbi.nlm.nih.gov/9637705/
https://pubmed.ncbi.nlm.nih.gov/17369473/
https://pubmed.ncbi.nlm.nih.gov/10559511/

https://pubmed.ncbi.nlm.nih.gov/9690910/
https://pubmed.ncbi.nlm.nih.gov/12045173/

+ 展开

カスタマーフィードバック

: Data from [BMC Pharmacol Toxicol, 2013, 14, 15]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer [ Cell Rep, 2025, 44(6):115792]	PubMed: 40483692
The Molecular Chaperone TCP1 Affects Carcinogenicity and Is a Potential Therapeutic Target for Acute Myeloid Leukemia [ Pharmaceutics, 2025, 17(5)557]	PubMed: 40430849
Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805]	PubMed: 39581704
Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs [ EMBO Rep, 2024, 10.1038/s44319-024-00346-9]	PubMed: 39668245
Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins [ Cancers (Basel), 2022, 14(9)2327]	PubMed: 35565457
Ultra-fast proteomics with Scanning SWATH [ Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4]	PubMed: 33767396
The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury [ Neurobiol Dis, 2021, 152:105294]	PubMed: 33549720
Atorvastatin potentiates the chemosensitivity of human liver cancer cells to cisplatin via downregulating YAP1 [ Oncol Lett, 2021, 21(2):82]	PubMed: 33363619
The MEK5-ERK5 kinase axis controls lipid metabolism in small cell lung cancer. [ Cancer Res, 2020, canres.1027.2019]	PubMed: 31969375
Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway [ Stem Cell Res Ther, 2020, 11(1):350]	PubMed: 32787917

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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