Azeliragon (TTP488)

製品コードS6415 バッチS641501

印刷

化学情報

Chemical Structure Synonyms PF-04494700 Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C32H38ClN3O2
分子量 532.12 CAS No. 603148-36-3
Solubility (25°C)* 体外 DMSO 120 mg/mL (225.51 mM)
Ethanol 100 mg/mL (187.92 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD.
in vivo

Preclinical studies in animal models of alzheimer disease (tgAPPSwedish/London) have shown azeliragon to decrease Aβ plaque deposition; reduce total Aβ brain concentration while increasing plasma Aβ levels; decrease sAPPβ while increasing sAPPα; reduce levels of inflammatory cytokines; and slow cognitive decline and improve cerebral blood flow[1].

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/29616709/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

S100A8/A9 innate immune signaling as a distinct mechanism driving progression of smoking-related breast cancers [ Oncogene, 2025, 44(15):1051-1062] PubMed: 39856330
Circulating HMGB2 Is Associated With Angiographic Coronary Collateralization in Diabetic Patients With Chronic Total Occlusion and Impairs Vessel Growth via NLRP3 [ Circ J, 2025, 10.1253/circj.CJ-24-0878] PubMed: 40368806
Macrophage RAGE activation is proinflammatory in NASH [ JCI Insight, 2024, e169138] PubMed: 38175729
RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity [ Cell Rep Med, 2023, 4(11):101266] PubMed: 37944530
Azeliragon inhibits PAK1 and enhances the therapeutic efficacy of AKT inhibitors in pancreatic cancer [ Eur J Pharmacol, 2023, 948:175703] PubMed: 37028543
Modulating the RAGE-Induced Inflammatory Response: Peptoids as RAGE Antagonists [ Chembiochem, 2023, 10.1002/cbic.202300503] PubMed: 37679300
The receptor for advanced glycation end products mediates dysfunction of airway epithelial barrier in a lipopolysaccharides-induced murine acute lung injury model [ Int Immunopharmacol, 2021, 93:107419] PubMed: 33548580
Tumor-derived HMGB1 induces CD62Ldim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer [ Oncogenesis, 2020, 9(9):82] PubMed: 32943604
Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE [ Front Pharmacol, 2020, 11:593832] PubMed: 33390976

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。