BAPTA-AM

製品コードS7534 バッチS753401

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₃₄H₄₀N₂O₁₈

分子量

764.68

CAS No.

126150-97-8

Solubility (25°C)*

体外

DMSO

20 mg/mL (26.15 mM)

Water

Insoluble

Ethanol

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	BAPTA-AMは、選択的で膜透過性のカルシウムキレーターです。
in vitro	BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. This compound exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells.
in vivo	BAPTA-AM abolishes the UDCA- and TUDCA-induced increases in Ca²⁺ levels or Ca2+-Dependent PKC-α phosphorylation, and neutralizes the cytoprotective effects of UDCA and TUDCA on the vagotomy-induced damage of the biliary tree in the BDL rats.

製品説明

BAPTA-AMは、選択的で膜透過性のカルシウムキレーターです。

in vitro

BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures.

This compound exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells.

in vivo

BAPTA-AM abolishes the UDCA- and TUDCA-induced increases in Ca²⁺ levels or Ca2+-Dependent PKC-α phosphorylation, and neutralizes the cytoprotective effects of UDCA and TUDCA on the vagotomy-induced damage of the biliary tree in the BDL rats.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Astrocytes
	濃度	10 μM
	反応時間
	実験の流れ
動物実験	動物モデル	BDL rats
	投薬量	~6 mg/kg
	投与方法	i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/11642660/
https://pubmed.ncbi.nlm.nih.gov/17826747/
https://pubmed.ncbi.nlm.nih.gov/16436655/

https://pubmed.ncbi.nlm.nih.gov/35696763/

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カスタマーフィードバック

: , , J Cell Mol Med, 2017, 21(7):1373-1387

: Data from [Data independently produced by , , Acta Pharm Sin B, 2018, 8(6):909-918]

: Data from [Data independently produced by , , CNS Neurosci Ther, 2017, 23(4):291-300]

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長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。