BAPTA-AM

製品コードS7534 バッチS753403

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C34H40N2O18
分子量 764.68 CAS No. 126150-97-8
Solubility (25°C)* 体外 DMSO 33 mg/mL (43.15 mM)
Water Insoluble
Ethanol Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 BAPTA-AM is a selective, membrane-permeable calcium chelator.
in vitro

BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. [1]

This compound exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells. [2]
in vivo

BAPTA-AM abolishes the UDCA- and TUDCA-induced increases in Ca2+ levels or Ca2+-Dependent PKC-α phosphorylation, and neutralizes the cytoprotective effects of UDCA and TUDCA on the vagotomy-induced damage of the biliary tree in the BDL rats. [3]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Astrocytes
濃度 10 μM
反応時間
実験の流れ
動物実験 動物モデル BDL rats
投薬量 ~6 mg/kg
投与方法 i.p.

参考

  • https://pubmed.ncbi.nlm.nih.gov/11642660/
  • https://pubmed.ncbi.nlm.nih.gov/17826747/
  • https://pubmed.ncbi.nlm.nih.gov/16436655/
  • https://pubmed.ncbi.nlm.nih.gov/35696763/

カスタマーフィードバック

, , J Cell Mol Med, 2017, 21(7):1373-1387

Data from [Data independently produced by , , Acta Pharm Sin B, 2018, 8(6):909-918]

Data from [Data independently produced by , , CNS Neurosci Ther, 2017, 23(4):291-300]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

PTH counteracts Hippo signaling via Src-dependent YAP stabilization to enhance bone marrow stromal cell differentiation [ JCI Insight, 2025, 10(16)e191245] PubMed: 40694420
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Piezo1 promotes intervertebral disc degeneration through the Ca2+/F-actin/Yap signaling axis [ Mol Med, 2025, 31(1):90] PubMed: 40057686
Calcium triggers calmodulin degradation to induce EGF receptor instability and overcome non-small cell lung cancer resistance to tyrosine kinase inhibitors [ J Biol Chem, 2025, 301(7):110305] PubMed: 40447190
Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca2+/Calpain and Calcineurin/TFEB signaling pathways [ PLoS One, 2025, 20(8):e0330282] PubMed: 40857264
TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway [ J Adv Res, 2024, S2090-1232(24)00499-5] PubMed: 39505144
Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy [ J Adv Res, 2024, S2090-1232(24)00555-1] PubMed: 39631519
SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II [ EMBO Rep, 2024, 25(11):4728-4748] PubMed: 39317734
Ammonia stress-induced heat shock factor 1 enhances white spot syndrome virus infection by targeting the interferon-like system in shrimp [ mBio, 2024, e0313623.] PubMed: 38358252
High-affinity tuning of single fluorescent protein-type indicators by flexible linker length optimization in topology mutant [ Commun Biol, 2024, 7(1):705] PubMed: 38851844

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。