受注:045-509-1970 |
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Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
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化学式 | C16H15F3N2O4 |
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分子量 | 356.30 | CAS No. | 71145-03-4 | ||||
Solubility (25°C)* | 体外 | DMSO | 71 mg/mL (199.27 mM) | ||||
Ethanol | 71 mg/mL (199.27 mM) | ||||||
Water | Insoluble | ||||||
体内 (毎回新しく調製した物を用意してください) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM. |
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in vitro | Bay K 8644 increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel[2] |
in vivo | Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.[3] |
細胞アッセイ | 細胞株 | 5TGM1 cells |
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濃度 | 10 nM | |
反応時間 | 30 minutes | |
実験の流れ | Cells were treated with indicated concentration of drug for 30 minutes. |
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動物実験 | 動物モデル | Male Sprague-Dawley rats |
投薬量 | 1, 10, 50 and 100 µg/kg | |
投与方法 | Jugular catheters |
Data from [Data independently produced by , , J Cell Physiol, 2018, doi:10.1002/jcp.27791]
Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis [ ACS Nano, 2021, 10.1021/acsnano.1c03517] | PubMed: 34506129 |
Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway [ Cell Biol Toxicol, 2021, 10.1007/s10565-021-09615-y] | PubMed: 34023961 |
Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate [ Journal of Advanced Research, 2020, 10.1016/j.jare.2020.10.005] | PubMed: None |
Sulfur Dioxide Activates Cl-/HCO3- Exchanger via Sulphenylating AE2 to Reduce Intracellular pH in Vascular Smooth Muscle Cells [ Front Pharmacol, 2019, 10:313] | PubMed: 30971931 |
Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling [Nie J, et al. J Cell Physiol, 2018, 10.1002/jcp.27791 ] | PubMed: 30488495 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。