β-Nicotinamide Mononucleotide

製品コードS5259 バッチS525902

印刷

化学情報

Chemical Structure Synonyms β-NM, NMN Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C11H15N2O8P
分子量 334.22 CAS No. 1094-61-7
Solubility (25°C)* 体外 Water 67 mg/mL (200.46 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase.
in vitro

Nicotinamide mononucleotide, the NAD+ precursor, rescues the NAD+/NADH ratio and exerts anti-senescent effects by activating SIRT1.[1]
in vivo

NMN reduces the loss of cochlear hair cells caused by cisplatin and improves hearing in C57BL/6 mice, by supplementation of NAD+ through de novo and salvage synthesis pathways.[2]

プロトコル(参考用のみ)

細胞アッセイ 細胞株 mouse AT2 cells strain MLE-12
濃度 500 μM
反応時間 --
実験の流れ

The mouse AT2 cells strain MLE-12 are cultured in DMEM with 10% FBS at 37 ℃ in a humidified atmosphere containing 5% CO2. Cells are treated with rapamycin (10 nM), bafilomycin (5 nM), 3 MA (3 mM), SRT1720 (4 μM), Ex527 (10 μM), NMN (500 μM), Olaparib (40 μM) and mitoquinone (50 nM). β-galactosidase staining is performed based on the manufacture s instructions. Relative protein expression levels are measured by Western blot. The level of NAD+/NADH is quantified by an NAD+/NADH detection kit.
動物実験 動物モデル C57BL/6 mice
投薬量 100 mg/kg
投与方法 i.g., i.p.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

NAD+ regulates nucleotide metabolism and genomic DNA replication [ Nat Cell Biol, 2023, 10.1038/s41556-023-01280-z] PubMed: 37957325
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism [ Mol Psychiatry, 2023, 10.1038/s41380-023-02372-w] PubMed: 38135757
Temperature-sensitive hydrogel dressing loaded with nicotinamide mononucleotide accelerating wound healing in diabetic mice [ Biomed Pharmacother, 2023, 10.1016/j.biopha.2023.115431] PubMed: 37688988
β-nicotinamide mononucleotide rescues the quality of aged oocyte and improves subsequent embryo development in pigs [ PLoS One, 2023, 18(10):e0291640] PubMed: 37796824
DePARylation is critical for S phase progression and cell survival [ bioRxiv, 2023, 2023.07.31.551317] PubMed: 37577639
DePARylation is critical for S phase progression and cell survival [ bioRxiv, 2023, 2023.07.31.551317] PubMed: 37577639
Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation [ Cell Death Differ, 2022, 10.1038/s41418-022-00992-3] PubMed: 35568718
Administration of nicotinamide mononucleotide improves oocyte quality of obese mice [ Cell Prolif, 2022, e13303] PubMed: 35811338
DNA damage contributes to age-associated differences in SARS-CoV-2 infection [ Aging Cell, 2022, 21(12):e13729] PubMed: 36254583
Oocytes could rearrange immunoglobulin production to survive over adverse environmental stimuli [ Front Immunol, 2022, 13:990077] PubMed: 36405746

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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