β-nicotinamide mononucleotide (NMN)

製品コードS5259 バッチS525903

化学情報

	Synonyms	β-NM, NMN	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₁₁H₁₅N₂O₈P
	分子量	334.22	CAS No.	1094-61-7
Solubility (25°C)*	体外	Water	67 mg/mL (200.46 mM)
		DMSO	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase.
in vitro	Nicotinamide mononucleotide, the NAD+ precursor, rescues the NAD+/NADH ratio and exerts anti-senescent effects by activating SIRT1.^[1]
in vivo	NMN reduces the loss of cochlear hair cells caused by cisplatin and improves hearing in C57BL/6 mice, by supplementation of NAD+ through de novo and salvage synthesis pathways.^[2]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	mouse AT2 cells strain MLE-12
	濃度	500 μM
	反応時間	--
	実験の流れ	The mouse AT2 cells strain MLE-12 are cultured in DMEM with 10% FBS at 37 ℃ in a humidified atmosphere containing 5% CO₂. Cells are treated with rapamycin (10 nM), bafilomycin (5 nM), 3 MA (3 mM), SRT1720 (4 μM), Ex527 (10 μM), NMN (500 μM), Olaparib (40 μM) and mitoquinone (50 nM). β-galactosidase staining is performed based on the manufacture s instructions. Relative protein expression levels are measured by Western blot. The level of NAD+/NADH is quantified by an NAD+/NADH detection kit.
動物実験	動物モデル	C57BL/6 mice
	投薬量	100 mg/kg
	投与方法	i.g., i.p.

参考

https://pubmed.ncbi.nlm.nih.gov/33609723/
https://pubmed.ncbi.nlm.nih.gov/34089817/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation [ Nat Commun, 2025, 16(1):212]	PubMed: 39747079
Histidine triad nucleotide-binding protein 2 attenuates doxorubicin-induced cardiotoxicity through restoring lysosomal function and promoting autophagy in mice [ MedComm (2020), 2025, 6(3):e70075]	PubMed: 39968501
SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation [ PLoS Pathog, 2025, 21(5):e1013163]	PubMed: 40344161
Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging [ Sci Adv, 2025, 11(16):eads1842]	PubMed: 40249823
Inactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53 [ Cell Death Differ, 2024, 10.1038/s41418-024-01428-w]	PubMed: 39733217
DePARylation is critical for S phase progression and cell survival [ Elife, 2024, 12RP89303]	PubMed: 38578205
SIRT1 stabilizes β-TrCP1 to inhibit Snail1 expression in maintaining intestinal epithelial integrity to alleviate colitis [ Cell Mol Gastroenterol Hepatol, 2024, S2352-345X(24)00108-5]	PubMed: 38729522
β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK Pathway [ Antioxidants (Basel), 2024, 14(1)34]	PubMed: 39857368
Loss of the mitochondrial carrier, SLC25A1, during embryogenesis induces a unique senescence program controlled by p53 [ bioRxiv, 2024, 2023.07.18.549409]	PubMed: 37503155
NAD+ regulates nucleotide metabolism and genomic DNA replication [ Nat Cell Biol, 2023, 10.1038/s41556-023-01280-z]	PubMed: 37957325

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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