BHQ

製品コードS3628 バッチS362801

印刷

化学情報

Synonyms

2,5-di-t-butyl-1,4-benzohydroquinone

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₄H₂₂O₂

分子量

222.32

CAS No.

88-58-4

Solubility (25°C)*

体外

Ethanol

40 mg/mL (179.92 mM)

DMSO

10 mg/mL (44.98 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%Ethanol 1 30%PEG300 2 65%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	2.000mg/ml (9.00mM)	Taking the 1 mL working solution as an example, add 50 μL of 40 mg/ml clarified Ethanol stock solution to 300 μL of PEG300, mix evenly to clarify it; then continue to add 650 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	BHQ（2,5-ジ-t-ブチル-1,4-ベンゾヒドロキノン）は、サルコ/小胞体Ca2+-ATPase（SERCA）の強力かつ選択的な阻害剤です。
in vitro	2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) has been described as a rather selective sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor. However, this compound is not very specific, as it hits other sites of action besides SERCA. It is shown, in fact, to reduce passive Ca2+ leakage from internal stores of permeabilized A7r5 vascular smooth muscle cells and to inhibit plasma membrane Ca2+ influx in parotid acinar cells, rat thymic lymphocytes, and GH3 pituitary cells. This chemical affects both endothelial and smooth muscle functions in rat aorta rings in vitro. It induces endothelium-dependent relaxation by stimulating the NO synthase pathway, via activation of Ca2+ influx through Ni2+-sensitive Ca2+ channels in the endothelial cells. This compound exhibits pleiotypic effects on rings deprived of endothelium by inducing both a myotonic response, dependent on the activation of Ca2+ influx via a Ni2+-sensitive pathway, and a myolytic effect, possibly dependent on either the depletion of intracellular Ca2+ stores or antagonism of Ca2+ entry via L-type Ca2+ channels. It is a lipophilic, membrane permeable molecule, capable of generating superoxide anion at both sides of the plasmalemma.

製品説明

BHQ（2,5-ジ-t-ブチル-1,4-ベンゾヒドロキノン）は、サルコ/小胞体Ca2+-ATPase（SERCA）の強力かつ選択的な阻害剤です。

in vitro

2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) has been described as a rather selective sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor. However, this compound is not very specific, as it hits other sites of action besides SERCA. It is shown, in fact, to reduce passive Ca2+ leakage from internal stores of permeabilized A7r5 vascular smooth muscle cells and to inhibit plasma membrane Ca2+ influx in parotid acinar cells, rat thymic lymphocytes, and GH3 pituitary cells. This chemical affects both endothelial and smooth muscle functions in rat aorta rings in vitro. It induces endothelium-dependent relaxation by stimulating the NO synthase pathway, via activation of Ca2+ influx through Ni2+-sensitive Ca2+ channels in the endothelial cells. This compound exhibits pleiotypic effects on rings deprived of endothelium by inducing both a myotonic response, dependent on the activation of Ca2+ influx via a Ni2+-sensitive pathway, and a myolytic effect, possibly dependent on either the depletion of intracellular Ca2+ stores or antagonism of Ca2+ entry via L-type Ca2+ channels. It is a lipophilic, membrane permeable molecule, capable of generating superoxide anion at both sides of the plasmalemma.

プロトコル(参考用のみ)

参考

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572887/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering [ Diabetes, 2022, 71(8):1660-1678]	PubMed: 35594380
Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity [ Oncogene, 2021, 40(6):1128-1146]	PubMed: 33323966

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。