Bifonazole

製品コードS1854 バッチS185402

印刷

化学情報

Synonyms

Bay h 4502,(±)-bifonazole

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₂₂H₁₈N₂

分子量

310.39

CAS No.

60628-96-8

Solubility (25°C)*

体外

DMSO

62 mg/mL (199.74 mM)

Ethanol

20 mg/mL (64.43 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	3.1mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 62 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5 %DMSO 1 95 %Corn oil この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.44mg/ml (1.42mM)	Taking the 1 mL working solution as an example, add 50 μL of 8.8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Bifonazole (Bay h 4502,(±)-bifonazole)は、置換イミダゾール系のFungal剤です。
in vitro	Bifonazole, a broad spectrum antifungal agent, inhibits monooxygenase activity and induces a type II binding spectrum in 2B4dH(H226Y), a modified enzyme previously crystallized in the presence of 4-(4-chlorophenyl)imidazole (CPI). This compound (40 mM) releases Ca2+ from the store sensitive to 1 mM thapsigargin, an endopolasmic reticulum Ca2+ pump inhibitor. It per se induces capacitative Ca2+ entry while reduces 1 mM thapsigargin-induced capacitative Ca2+ entry. This chemical is calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells. It acts through allosteric regulation and detachment of glycolytic enzymes from cytoskeleton. This agent blocks PGE2 formation induced by 2 μm and 4 μm arachidonic acid clearly better than at 6 or 10 μm of the agonist. It shows the same characteristics in MC3T3-E1 and UMR-106 cells stimulated by ionomycin or various concentrations of arachidonic acid.
in vivo	Bifonazole, but not clotrimazole, exhibits the characteristics of a peroxisome proliferator including hepatomegaly (increase in liver:body weight ratio), up to a 4-fold induction of lauric acid omega-hydroxylase activity and an 8-fold induction of palmitoyl-CoA oxidation by rat liver peroxisomes. This compound also induces P402B1/2B2, P4503A and P4501A1, but not P4502E1.

プロトコル(参考用のみ)

参考

https://pubmed.ncbi.nlm.nih.gov/16373351/
https://pubmed.ncbi.nlm.nih.gov/11767287/
https://pubmed.ncbi.nlm.nih.gov/9544799/

https://pubmed.ncbi.nlm.nih.gov/10903961/
https://pubmed.ncbi.nlm.nih.gov/8571391/

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カスタマーフィードバック

: Data from [Data independently produced by , , Nature, 2018, 560(7718):372-376]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Transcription factor Hap2p regulates antioxidant stress responses to maintain miconazole resistance in Candida albicans [ Mycology, January 6, 2025, 16(3):1386-1399]	PubMed: 40937141
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination [ Nature, August 2018, 560(7719):440-444]	PubMed: 30046109
Transcription factor Hap2p regulates antioxidant stress responses to maintain miconazole resistance in Candida albicans [ Mycology, 2025, 1386-1399]	PubMed: 40937141
Identifying novel radioprotective drugs via salivary gland tissue chip screening [ bioRxiv, 2023, Preprint]	PubMed: 37503292
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination [Hubler Z, et al. Nature, 2018, 560(7718):372-376]	PubMed: 30046109
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination [ Nature, 2018, 372-376]	PubMed: 30046109
Identification of drugs that restore primary cilium expression in cancer cells [ Oncotarget, 2016, 9975-9992]	PubMed: 26862738

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。