Bifonazole

製品コードS1854 バッチS185402

印刷

化学情報

Chemical Structure Synonyms Bay h 4502,(±)-bifonazole Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C22H18N2
分子量 310.39 CAS No. 60628-96-8
Solubility (25°C)* 体外 DMSO 62 mg/mL (199.74 mM)
Ethanol 20 mg/mL (64.43 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Bifonazole (Bay h 4502,(±)-bifonazole) is a substituted imidazole antifungal agent.
in vitro

Bifonazole, a broad spectrum antifungal agent, inhibits monooxygenase activity and induces a type II binding spectrum in 2B4dH(H226Y), a modified enzyme previously crystallized in the presence of 4-(4-chlorophenyl)imidazole (CPI). [1] This compound (40 mM) releases Ca2+ from the store sensitive to 1 mM thapsigargin, an endopolasmic reticulum Ca2+ pump inhibitor. It per se induces capacitative Ca2+ entry while reduces 1 mM thapsigargin-induced capacitative Ca2+ entry. [2] This chemical is calmodulin antagonists which most effectively reduce glycolysis and ATP level in B16 melanoma cells. It acts through allosteric regulation and detachment of glycolytic enzymes from cytoskeleton. [3] This agent blocks PGE2 formation induced by 2  μm and 4 μm arachidonic acid clearly better than at 6 or 10 μm of the agonist. It shows the same characteristics in MC3T3-E1 and UMR-106 cells stimulated by ionomycin or various concentrations of arachidonic acid. [4]
in vivo

Bifonazole, but not clotrimazole, exhibits the characteristics of a peroxisome proliferator including hepatomegaly (increase in liver:body weight ratio), up to a 4-fold induction of lauric acid omega-hydroxylase activity and an 8-fold induction of palmitoyl-CoA oxidation by rat liver peroxisomes. This compound also induces P402B1/2B2, P4503A and P4501A1, but not P4502E1. [5]

プロトコル(参考用のみ)

参考

  • https://pubmed.ncbi.nlm.nih.gov/16373351/
  • https://pubmed.ncbi.nlm.nih.gov/11767287/
  • https://pubmed.ncbi.nlm.nih.gov/9544799/
  • https://pubmed.ncbi.nlm.nih.gov/10903961/
  • https://pubmed.ncbi.nlm.nih.gov/8571391/

カスタマーフィードバック

Data from [Data independently produced by , , Nature, 2018, 560(7718):372-376]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination [Hubler Z, et al. Nature, 2018, 560(7718):372-376] PubMed: 30046109

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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