Blebbistatin

製品コードE1249 バッチE124901

化学情報

	Synonyms		Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₁₈H₁₆N₂O₂
	分子量	292.33	CAS No.	674289-55-5
Solubility (25°C)*	体外	DMSO	58 mg/mL (198.4 mM)
		Ethanol	5 mg/mL (17.1 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Blebbistatin is a selective inhibitor of non-muscle myosin II (NMII). It also potently inhibits several striated muscle myosins as well as vertebrate nonmuscle myosin IIA and IIB with IC50 values ranging from 0.5 to 5 μM. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function.

製品説明

Blebbistatin is a selective inhibitor of non-muscle myosin II (NMII). It also potently inhibits several striated muscle myosins as well as vertebrate nonmuscle myosin IIA and IIB with IC50 values ranging from 0.5 to 5 μM. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function.

プロトコル(参考用のみ)

参考

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Bioelectric stimulation controls tissue shape and size [ Nat Commun, 2024, 15(1):2938]	PubMed: 38580690
The Mechanics of Tumor Cells Dictate Malignancy via Cytoskeleton-Mediated APC/Wnt/β-Catenin Signaling [ Research -Wash D C), 2023, 6:0224]	PubMed: 37746658
The Mechanics of Tumor Cells Dictate Malignancy via Cytoskeleton-Mediated APC/Wnt/β-Catenin Signaling [ Research (Wash D C), 2023, 6:0224]	PubMed: 37746658
CDR1as promotes arrhythmias in myocardial infarction via targeting the NAMPT-NAD+ pathway [ Biomed Pharmacother, 2023, 165:115267]	PubMed: 37542851
Staphylococcal Enterotoxin C2 Mutant-Induced Antitumor Immune Response Is Controlled by CDC42/MLC2-Mediated Tumor Cell Stiffness [ Int J Mol Sci, 2023, 24(14)11796]	PubMed: 37511553
Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning [ Int. J. Mol. Sci, 2023, 24(7), 6525]	PubMed: None
Prolonged Piezo1 Activation Induces Cardiac Arrhythmia [ Int J Mol Sci, 2023, 24(7)6720]	PubMed: 37047693
Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system [ Neoplasia, 2023, 10.1016/j.neo.2023.100948]	PubMed: 37944353
Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture [ Development, 2023, 150(14)dev201386]	PubMed: 37401411
Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture [ Development, 2023, 150(14)dev201386]	PubMed: 37401411

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。