BML-190

製品コードS2854 バッチS285401

化学情報

	Synonyms	IMMA	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₃H₂₃ClN₂O₄
	分子量	426.89	CAS No.	2854-32-2
Solubility (25°C)*	体外	DMSO	22 mg/mL (51.53 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	BML-190 (IMMA) is a selective cannabinoid CB2 receptor inverse agonist with K_i of 435 nM, with 50-fold selectivity over CB1 receptor.
in vitro	BML-190 has 50-fold selectivity for CB2 receptors over CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, BML-190 potentiates the forskolin-stimulated accumulation of cAMP. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 μM of BML-190 decreases inositol phosphates accumulation by 38%. ^[1] BML-190 is an aminoalkylindole. BML-190 is found to yield at least 15 metabolic products. ^[2] BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction. ^[3]

製品説明

BML-190 (IMMA) is a selective cannabinoid CB2 receptor inverse agonist with K_i of 435 nM, with 50-fold selectivity over CB1 receptor.

in vitro

BML-190 has 50-fold selectivity for CB2 receptors over CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, BML-190 potentiates the forskolin-stimulated accumulation of cAMP. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 μM of BML-190 decreases inositol phosphates accumulation by 38%. ^[1] BML-190 is an aminoalkylindole. BML-190 is found to yield at least 15 metabolic products. ^[2] BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction. ^[3]

プロトコル(参考用のみ)

細胞アッセイ	細胞株	293/CB2 cells with [³H]adenine (1 μCi/mL)
	濃度	0 μM -100 μM
	反応時間	20 hours–24 hours
	実験の流れ	293/CB2 cells are labeled with [³H]adenine (1 μCi/mL) in MEM with 1% FBS for 20 hours-24 hours. Labelled cells are challenged with 50 μM forskolin and appropriate BML-190 for 30 minutes at 37°C and assayed for cAMP accumulation. For IP assays, 2 × 10⁵ 293/CB2 cells are transiently transfected with 16z44 and/or pcDNA3 using transfection reagents. Cells are labelled, challenged with BML-190 and assayed for IP production. Triplicates are performed for each data point and at least three separate trials are done for each ligand.

参考

カスタマーフィードバック

: , , University of Alberta, 2014.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil. [ Int J Mol Sci, 2020, 21(7)]	PubMed: 32218156
Novel Therapeutic Approaches for Inflammatory Bowel Disease. [Yahya Muhammad Fiteih , et al. University of Alberta, 2014, Yahya Muhammad Fiteih ]

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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