BMS309403

製品コードS6622 バッチS662201

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C31H26N2O3
分子量 474.55 CAS No. 300657-03-8
Solubility (25°C)* 体外 DMSO 95 mg/mL (200.18 mM)
Ethanol 18 mg/mL (37.93 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 BMS309403 is a small-molecule FABP4 inhibitor with nM affinity (Kd=4 nM for FABP4) and >100-fold selectivity against FABP5 as well as the heart isoform FABP3.
in vitro

Treatment of BMS309403 (FABP4 inhibitor) comobined with SSO (CD36 inhibitor) significantly decreases the breast cancer cell viability, proliferative, migratory, and invasive abilities over 72 h. Inhibiting either at recommended concentrations does not significantly decrease the breast cancer cell viability over 72 h. Treatment with both SSO and BMS309403 results in clustering of cells and increased lipid content, indicating an inability to metabolise lipids resulting potentially in lipotoxicity-induced apoptosis.[1]
in vivo

Treatment with either BMS309403 or SSO alone decreases the rate of tumour formation and the combination of BMS309403 and SSO significantly decreased the rate of tumour formation.

プロトコル(参考用のみ)

細胞アッセイ 細胞株 Humen breast cancer cell lines
濃度 20 μM
反応時間 72 h
実験の流れ

Cell viability after CD36 knockout or treatment with SSO and BMS-309403 is determined by seeding 2500 cells in 96-well plate, and cultured for 24 h, after which treatment agent is added at appropriate concentration and maintained for 72 h. Cell viabilities is evaluated at 6, 12, 24, 36, 48, 60 and 72 h using the EZ-CYTOX cell viability kit.
動物実験 動物モデル Nude mice bearing MDA-MB-231 xenograft tumors
投薬量 15 mg/kg
投与方法 o.g.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis [ Cell Death Dis, 2022, 13(4):333] PubMed: 35410456
FABP4-mediated lipid droplet formation in Streptococcus uberis-infected macrophages supports host defence [ Vet Res, 2022, 53(1):90] PubMed: 36371263
Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer [ NPJ Breast Cancer, 2021, 7(1):129] PubMed: 34561446

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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