BMS309403

製品コードS6622 バッチS662202

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₃₁H₂₆N₂O₃

分子量

474.55

CAS No.

300657-03-8

Solubility (25°C)*

体外

DMSO

95 mg/mL (200.18 mM)

Ethanol

18 mg/mL (37.93 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	6.000mg/ml (12.64mM)	Taking the 1 mL working solution as an example, add 50 μL of 120 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	BMS309403 is a small-molecule FABP4 inhibitor with nM affinity (Kd=4 nM for FABP4) and >100-fold selectivity against FABP5 as well as the heart isoform FABP3.
in vitro	Treatment of BMS309403 (FABP4 inhibitor) comobined with SSO (CD36 inhibitor) significantly decreases the breast cancer cell viability, proliferative, migratory, and invasive abilities over 72 h. Inhibiting either at recommended concentrations does not significantly decrease the breast cancer cell viability over 72 h. Treatment with both SSO and this compound results in clustering of cells and increased lipid content, indicating an inability to metabolise lipids resulting potentially in lipotoxicity-induced apoptosis.^[1]
in vivo	Treatment with either BMS309403 or SSO alone decreases the rate of tumour formation and the combination of this compound and SSO significantly decreased the rate of tumour formation.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Humen breast cancer cell lines
	濃度	20 μM
	反応時間	72 h
	実験の流れ	Cell viability after CD36 knockout or treatment with SSO and BMS-309403 is determined by seeding 2500 cells in 96-well plate, and cultured for 24 h, after which treatment agent is added at appropriate concentration and maintained for 72 h. Cell viabilities is evaluated at 6, 12, 24, 36, 48, 60 and 72 h using the EZ-CYTOX cell viability kit.
動物実験	動物モデル	Nude mice bearing MDA-MB-231 xenograft tumors
	投薬量	15 mg/kg
	投与方法	o.g.

参考

https://pubmed.ncbi.nlm.nih.gov/34561446/
https://pubmed.ncbi.nlm.nih.gov/21296956/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

FABP4-dependent fatty acid oxidation-fueled mitochondrial ROS induces the mobilization of cellular iron and facilitates Trypanosoma cruzi proliferation in murine adipocytes [ mBio, 2025, e0218025.]	PubMed: 40919813
Adipocyte-derived factors induce adherent to suspension transition in breast and pancreatic cancer cells through lipid metabolic alteration [ Sci Rep, 2025, 15(1):30552]	PubMed: 40836054
Identification of Fatty Acid-Binding Protein 4 as a Potential Biomarker and Therapeutic Target for Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis [ Kidney Dis (Basel), 2025, 11(1):75-89]	PubMed: 40098819
Olaparib promotes FABP4 expression and reduces antitumor effect in ovarian cancer cells with a BRCA1 mutation [ Oncol Lett, 2025, 29(2):67]	PubMed: 39619421
FABP4-mediated lipid metabolism promotes TNBC progression and breast cancer stem cell activity [ Cancer Lett, 2024, 604:217271]	PubMed: 39306229
Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis [ Cell Death Dis, 2022, 13(4):333]	PubMed: 35410456
FABP4-mediated lipid droplet formation in Streptococcus uberis-infected macrophages supports host defence [ Vet Res, 2022, 53(1):90]	PubMed: 36371263
Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer [ NPJ Breast Cancer, 2021, 7(1):129]	PubMed: 34561446

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。