Borneol

製品コードS3605 バッチS360501

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C10H18O
分子量 154.25 CAS No. 507-70-0
Solubility (25°C)* 体外 DMSO 30 mg/mL (194.48 mM)
Ethanol 30 mg/mL (194.48 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Borneol is a bicyclic monoterpenoid compound extracted from medicinal plants such as Blumea balsamifera, and Dryobalanops aromatica. It is a TRPM8 agonist that increases ocular surface wetness.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
in vitro Borneol activates TRPM8 channel in a temperature- and dose-dependent manner. Borneol at micromolar concentrations do not affect the viability of human corneal epithelial cells. Borneol has been found to activate TRPV3 channel, which belongs to the heat-activated vanilloid family of TRP channels[1]. Borneol can potentiate (EC50 = 248 μM) or directly activate (> 1.5 mM) the GABAA receptor, activate the TRPV3 channel (EC50 = 3.45 ± 0.13 mM), and inhibit the TRPA1 channel (IC50 = 0.5 ± 0.3 or 0.20 ± 0.06 mM)[2].
in vivo Borneol is widely used in ophthalmic preparations and classic formulas of Traditional Chinese Medicine to treat various diseases including oculopathies, oral ulcers, sore throat, skin diseases and mild neurological disorders, and found to produce anti-inflammatory, anti-bacterial and analgesic effects. Borneol can increase tear secretion via activating the cold-sensing TRPM8 channel in the cornea[1]. borneol may facilitate the delivery of other effective components and enhance their effects in combinatorial herbal formulas. Thus, borneol is also orally administered as an adjuvant component for the treatment of a variety of diseases. topical borneol provides analgesic effects in three different mouse models of pain[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 HEK293 and HCE cells
濃度 --
反応時間 24 h
実験の流れ

The viability of HEK293 and HCE cells is measured with WST-1 reagent. Briefly, cells are seeded in 96-well plates to reach a confluency of 50–60%. Borneol or menthol is added into the cell culture medium and incubated for 24 h. WST-1 (10 μl) is then added into each well and incubated for 2 h. Absorbance at 450 nm (A450) and 690 nm (A690) is measured in a plate reader. The subtracted value (A450-A690) is used to evaluate viability of the cells.

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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