bpV (HOpic)

製品コードS8651 バッチS865101

印刷

化学情報

Chemical Structure Synonyms Bisperoxovanadium (HOpic) Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C6H4NO8V.2K
分子量 347.24 CAS No. 722494-26-0
Solubility (25°C)* 体外 Water 69 mg/mL (198.7 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.
in vitro 1 μM BpV(Hopic) treatment is capable of increasing the in vitro migration of C2C12 myoblasts, without significantly reducing their ability to differentiate and fuse into multinucleated myotubes. The effects on myoblast migration is in conjuction with enhanced AKT and ERK1/2 signaling[2].
in vivo Pharmacological inhibition of PTEN with bpV(HOpic) exacerbates renal dysfunction and promotes tubular damage in mice with IRI(renal ischemia/reperfusion injury) compared with vehicle-treated mice with IRI. PTEN inhibition enhances tubular cell apoptosis in kidneys with IRI, which is associated with excessive caspase-3 activation. Furthermore, PTEN inhibition expands the infiltration of neutrophils and macrophages into kidneys with IRI, which is accompanied by increased expression of the proinflammatory molecules[3].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 C2C12 myoblasts
濃度 1 μM or 10 μM
反応時間 72 h
実験の流れ

C2C12 myoblasts are grown to high confluency and triggered to differentiate in the presence of DM, supplemented with 1 μM or 10 μM BpV(Hopic).
動物実験 動物モデル mouse model of ischemia-reperfusion injury (C57BL/6 mice, 8-12 weeks old)
投薬量 200 μg/kg
投与方法 i.p.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration [ Protein Cell, 2023, 14(5):350-368] PubMed: 37155312
Malic Enzyme 1 as a Novel Anti-Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury [ Adv Sci (Weinh), 2023, 10(13):e2205436] PubMed: 36840630
Downregulation of KLF10 contributes to the regeneration of survived renal tubular cells in cisplatin-induced acute kidney injury via ZBTB7A-KLF10-PTEN axis [ Cell Death Discov, 2023, 9(1):82] PubMed: 36878898
The anti-angiogenesis mechanism of Geniposide on rheumatoid arthritis is related to the regulation of PTEN [ Inflammopharmacology, 2022, 30(3):1047-1062] PubMed: 35389123
Primary Cilia Restrain PI3K-AKT Signaling to Orchestrate Human Decidualization [ Int J Mol Sci, 2022, 23(24)15573] PubMed: 36555215
Geniposide restricts angiogenesis in experimentary arthritis via inhibiting Dnmt1-mediated PTEN hypermethylation [ Int Immunopharmacol, 2022, 111:109087] PubMed: 35908504
Progerin modulates the IGF-1R/Akt signaling involved in aging [ Sci Adv, 2022, 8(27):eabo0322] PubMed: 35857466
Single-Oocyte Gene Expression Suggests That Curcumin Can Protect the Ovarian Reserve by Regulating the PTEN-AKT-FOXO3a Pathway [ Int J Mol Sci, 2021, 22(12)6570] PubMed: 34207376
Hormone-Like Effects of 4-Vinylcyclohexene Diepoxide on Follicular Development [ Front Cell Dev Biol, 2020, 8:587] PubMed: 32850784
Inhibition of PTEN activity promotes IB4-positive sensory neuronal axon growth [ J Cell Mol Med, 2020, 10.1111/jcmm.15648] PubMed: 32744427

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。