BQ-123

製品コードS7883 バッチS788301

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C31H42N6O7
分子量 610.7 CAS No. 136553-81-6
Solubility (25°C)* 体外 DMSO (warmed with 50ºC water bath) 100 mg/mL (163.74 mM)
Ethanol (warmed with 50ºC water bath) 92 mg/mL (150.64 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
in vitro In porcine aortic vascular smooth muscle cells, BQ-123 selectively inhibits ETA-mediated contraction. [1] In rat vascular smooth muscle cells, this compound inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis. [2]
in vivo In rats, BQ-123 (1 mg/kg, i.v.) ameliorates myocardial ischemic-reperfusion injury. [3] In rats with pentylenetetrazole (PTZ)-induced tonic-clonic seizures, this compound (3 mg/kg, i.v.) potently impedes the formation and spread of seizure. [4] In pregnant C57BL/6 mice, this chemical (6.7 mg/kg, i.p.) prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. [5]

プロトコル(参考用のみ)

動物実験 動物モデル Male Wistar rats
投薬量 1 mg/kg
投与方法 i.v.

参考

  • https://pubmed.ncbi.nlm.nih.gov/1282942/
  • https://pubmed.ncbi.nlm.nih.gov/1318228/
  • https://pubmed.ncbi.nlm.nih.gov/20888175/
  • https://pubmed.ncbi.nlm.nih.gov/24449761/
  • https://pubmed.ncbi.nlm.nih.gov/25230003/

カスタマーフィードバック

Data from [Data independently produced by , , Br J Pharmacol, 2016, 173(6):1018-32. ]

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Jawbone-like organoids generated from human pluripotent stem cells [ Nat Biomed Eng, 2025, 10.1038/s41551-025-01419-3] PubMed: 40603745
Endogenous hydrogen sulfide persulfidates endothelin type A receptor to inhibit pulmonary arterial smooth muscle cell proliferation [ Redox Biol, 2025, 80:103493] PubMed: 39823888
Enhanced vascular contraction induced by exposure to angiotensin II mediated by endothelin-1 biosynthesis following PKCβ activation [ Am J Physiol Heart Circ Physiol, 2025, 328(3):H484-H495] PubMed: 39887322
Identification of ECE2 signaling in promoting non-small lung cancer progression through ET1/YAP1/MAGEA3 axis [ Sci Rep, 2025, 15(1):5626] PubMed: 39955423
Lead acetate deteriorates the improvement effect of L-arginine and tetrahydrobiopterin on endothelin-1 receptors activity in rat aorta [ Baghdad Sci J, 2023,  2023, 20(5 Suppl.)] PubMed: None
Lead acetate deteriorates the improvement effect of L-arginine and tetrahydrobiopterin on endothelin-1 receptors activity in rat aorta [ Baghdad Science Journal, 2023, 20(5 Suppl.)] PubMed: none
Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension [ J Mol Cell Cardiol, 2022, 171:16-29] PubMed: 35810662
Telmisartan attenuatesuric acid-induced epithelial-mesenchymal transition in renal tubular cells [ BioMed Research International, 2019-, 10.1155/2019/3851718] PubMed: None
Notch signaling activation induces cell death in MAPKi-resistant melanoma cells [Mikheil DM Pigment Cell Melanoma Res, 2019, 10.1111/pcmr.12764] PubMed: 30614626
Telmisartan Attenuates Uric Acid-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells. [ Biomed Res Int, 2019, 2019:3851718] PubMed: 30993112

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。