受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder 1 years -80°C in solvent |
|
化学式 | C31H42N6O7 |
|||
分子量 | 610.7 | CAS No. | 136553-81-6 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL warmed with 50ºC water bath (163.74 mM) | |
Ethanol | 92 mg/mL warmed with 50ºC water bath (150.64 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. |
---|---|
in vitro | In porcine aortic vascular smooth muscle cells, BQ-123 selectively inhibits ETA-mediated contraction. [1] In rat vascular smooth muscle cells, BQ-123 inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis. [2] |
in vivo | In rats, BQ-123 (1 mg/kg, i.v.) ameliorates myocardial ischemic-reperfusion injury. [3] In rats with pentylenetetrazole (PTZ)-induced tonic-clonic seizures, BQ-123 (3 mg/kg, i.v.) potently impedes the formation and spread of seizure. [4] In pregnant C57BL/6 mice, BQ-123 (6.7 mg/kg, i.p.) prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. [5] |
動物実験 | 動物モデル | Male Wistar rats |
---|---|---|
投薬量 | 1 mg/kg | |
投与方法 | i.v. |
Data from [Data independently produced by , , Br J Pharmacol, 2016, 173(6):1018-32. ]
Lead acetate deteriorates the improvement effect of L-arginine and tetrahydrobiopterin on endothelin-1 receptors activity in rat aorta [ Baghdad Science Journal, 2023, 20(5 Suppl.)] | PubMed: none |
Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension [ J Mol Cell Cardiol, 2022, 171:16-29] | PubMed: 35810662 |
Telmisartan attenuatesuric acid-induced epithelial-mesenchymal transition in renal tubular cells [ BioMed Research International, 2019-, 10.1155/2019/3851718] | PubMed: None |
Notch signaling activation induces cell death in MAPKi-resistant melanoma cells [Mikheil DM Pigment Cell Melanoma Res, 2019, 10.1111/pcmr.12764] | PubMed: 30614626 |
Telmisartan Attenuates Uric Acid-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells. [ Biomed Res Int, 2019, 2019:3851718] | PubMed: 30993112 |
L-arginine and tetrahydrobiopterin modulate endothelin-1A receptor activity in isolated rat aorta [ ZANCO, 2019, 31-2] | PubMed: None |
Evolution of the developmental plasticity and a coupling between left mechanosensory neuromasts and an adaptive foraging behavior [Fernandes VFL Dev Biol, 2018, 441(2):262-271] | PubMed: 29782817 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。