Brusatol

製品コードS7956 バッチS795602

化学情報

	Synonyms	NSC 172924	Storage (From the date of receipt)	3 years -20°C powder
	化学式	C₂₆H₃₂O₁₁
	分子量	520.53	CAS No.	14907-98-3
Solubility (25°C)*	体外	DMSO	100 mg/mL (192.11 mM)
		Water	Insoluble
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Brusatol (NSC 172924), isolated from the fruit of B. javanica, is a NRF2 inhibitor.
in vitro	Brusatol provokes a rapid and transient depletion of Nrf2 protein, through a posttranscriptional mechanism, in mouse Hepa-1c1c7 hepatoma cells and freshly isolated primary human hepatocytes ^[1].
in vivo	Brusatol inhibits Nrf2 signaling, reduces tumor burden, and ameliorates chemoresistance in both in vitro and in vivo cancer models^[1].

プロトコル(参考用のみ)

参考

[1] Adedamola Olayanju, et al. Free Radic Biol Med. 2015, 78: 202-212.

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis [ Redox Biol, 2024, 72:103137]	PubMed: 38642502
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment [ Iran J Immunol, 2024, 21(1)]	PubMed: 38314669
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination [ Adv Sci (Weinh), 2023, 10(14):e2204438]	PubMed: 36965071
Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke [ J Pharm Anal, 2023, 13(2):156-169]	PubMed: 36908855
Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer [ Cancers (Basel), 2023, 15(12)3089]	PubMed: 37370701
Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway [ World J Stem Cells, 2023, 15(11):1017-1034]	PubMed: 38058959
Targeting SELPLG/P-selectin glycoprotein ligand 1 in preclinical ARDS: Genetic and epigenetic regulation of the SELPLG promoter [ Pulm Circ, 2023, 13(1):e12206]	PubMed: 36873461
MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway [ Redox Biol, 2022, 53:102325]	PubMed: 35525026
KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H 2S axis and contributes to pancreatic cancer growth [ Acta Biochim Biophys Sin (Shanghai), 2022, 54(11):1731-1739]	PubMed: 36514219
Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway [ Exp Ther Med, 2022, 23(4):303]	PubMed: 35340877

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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