Buspirone HCl

製品コードS4256 バッチS425601

化学情報

	Synonyms	Buspirone hydrochloride	Storage (From the date of receipt)	3 years -20°C powder 1 years -80°C in solvent
	化学式	C₂₁H₃₁N₅O₂.HCl
	分子量	421.96	CAS No.	33386-08-2
Solubility (25°C)*	体外	DMSO	84 mg/mL (199.07 mM)
		Water	84 mg/mL (199.07 mM)
		Ethanol	36 mg/mL (85.31 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

製品説明	Buspirone(Buspirone hydrochloride) is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.
in vitro	Buspirone, a clinically effective non-benzodiazepine anxiolytic drug, causes inhibition of firing of these neurons when given by intravenous (ED50 = 0.011 mg/kg, i.v.), intraperitoneal (ED50 = 0.088 mg/kg, i.p.), and intragastric (effective dose = 1.0-20.0 mg/kg, i.g.) injection. Buspirone also inhibits these cells when it is administered to the outside of recorded neurons by microiontophoresis. ^[1] Buspirone is eliminated primarily by oxidative metabolism, which produces several hydroxylated metabolites, including 5-hydroxy-buspirone and 1-pyrimidinylpiperazine. ^[2]
in vivo	Buspirone (3 mg/rat, i.p.) dose dependently and completely inhibits shock-induced ultrasonic vocalization after systemic injection and after microinjection into the dorsal raphe nucleus of rats, a brain region rich in somatodendritic 5-HT1A receptors. ^[3] Buspirone (20 mg/kg) decreases immobility in the rat forced swim test. ^[4] Buspirone is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect in a zebrafish model of anxiety. ^[5] Buspirone dose-dependently reduces LID and improved l-DOPA-related motor performance due to action at the 5-HT(1A) receptor in l-DOPA-primed rats. Buspirone delayes LID development while improving l-DOPA's anti-parkinsonian efficacy indicating the potential long-term benefits of 5-HT(1A) agonists for reduction of l-DOPA-related side effects in l-DOPA-naive rats. ^[6]

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

(-)-Syringaresinol-4-O-β-D-glucopyranoside From Cortex Albizziae Inhibits Corticosterone-Induced PC12 Cell Apoptosis and Relieves the Associated Dysfunction [ Food Chem Toxicol, 2020, 30;141:111394]	PubMed: 32360906

(-)-Syringaresinol-4-O-β-D-glucopyranoside From Cortex Albizziae Inhibits Corticosterone-Induced PC12 Cell Apoptosis and Relieves the Associated Dysfunction [ Food Chem Toxicol, 2020, 30;141:111394]

PubMed: 32360906

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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