Butylparaben

製品コードS4584 バッチS458401

印刷

化学情報

Synonyms

Butyl parahydroxybenzoate, Butyl paraben, Butyl 4-hydroxybenzoate

Storage
(From the date of receipt)

3 years -20°C powder
1 years -80°C in solvent

化学式

C₁₁H₁₄O₃

分子量

194.23

CAS No.

94-26-8

Solubility (25°C)*

体外

DMSO

38 mg/mL (195.64 mM)

Water

38 mg/mL (195.64 mM)

Ethanol

38 mg/mL (195.64 mM)

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Butylparaben（パラヒドロキシ安息香酸ブチル、4-ヒドロキシ安息香酸ブチル）は、化粧品に一般的に使用される抗真菌防腐剤です。
in vitro	After butylparaben treatment, vimentin filaments in Sertolicells are disrupted. Sertoli cell cytoskeleton responds to butylparaben by exhibiting a marked collapse in vimentin filaments distribution.
in vivo	Butylparaben induces collapse of Sertoli cell vimentin filaments in vivo. Exposure of a postweaning mammal to butylparaben had an adverse effect on the secretion of testosterone and in the functions of the male reproductive system.

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Primary Sertoli cell
	濃度	0, 1, 100 and 1000 nmol/ml
	反応時間	6, 24h
	実験の流れ	Mixed cultures of Sertoli and spermatogenic cells are prepared from three-week-old SD rats. Single cells are obtained by gravity sedimentation and use of 50% trypsin-EDTA. Cells are finally suspended at a concentration of 1 × 10⁸cell/ml and maintained for 24 h in Dulbecco’s modified Eagle medium supplemented with 100 U/ml penicillin, 100 μg/ml streptomycin, and 10% fetal bovineserum. Thereafter, cells are maintained in serum-freemedium, which is changed every 24 h. At 72 h, spermatogenic cells are removed by treatment with hypotonic Tris buffer (20 mMTris–HCl, pH 7.4) for 5 min. The Sertoli cell-enriched cultures obtained are then maintained in serum-free medium for 24 h before being reseeded onto chamber slides. The samples are cultured for a further 5 days. Subsequently, they are exposed to 0, 1, 100 and 1000 nmol/ml butylparaben for 6 and 24 h. Some slides are stained with 0.5% toluidine blue for light microscopic observations, whereas the rest are used for vimentin immuno-histochemical analysis.
動物実験	動物モデル	Male Sprague–Dawley rats
	投薬量	1000 mg/kg
	投与方法	oral administration

参考

https://pubmed.ncbi.nlm.nih.gov/24444665/
https://pubmed.ncbi.nlm.nih.gov/12004923/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Butyl paraben promotes apoptosis in human trophoblast cells through increased oxidative stress-induced endoplasmic reticulum stress [ Environ Toxicol, 2018, 33(4):436-445]	PubMed: 29319206
Butyl paraben promotes apoptosis in human trophoblast cells through increased oxidative stress-induced endoplasmic reticulum stress [ Environmental Toxicology, 2018, 436-445]	PubMed: nan

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。