受注:045-509-1970 |
技術サポート:[email protected] 平日9:00〜18:00 1営業日以内にご連絡を差し上げます |
Synonyms | N/A | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C11H7IN2O4 |
|||
分子量 | 358.09 | CAS No. | 314054-00-7 | |
Solubility (25°C)* | 体外 | DMSO | 72 mg/mL (201.06 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway. |
---|---|
in vitro | C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. It directly targets mouse STING (mmSTING) but not human STING (hsSTING)[1]. |
in vivo | C-176 attenuates STING-associated autoinflammatory disease in mice[1]. |
細胞アッセイ | 細胞株 | H526 cells |
---|---|---|
濃度 | 1 μM | |
反応時間 | 48 h | |
実験の流れ | Cells were treated 1 μM C176 and 1 μM AZD1775 for 48 h |
|
動物実験 | 動物モデル | C57BL/6J mice |
投薬量 | 750 nmol/200 μL | |
投与方法 | ip |
|
Up-regulation of HSP90α in HDM-induced asthma causes pyroptosis of airway epithelial cells by activating the cGAS-STING-ER stress pathway [ Int Immunopharmacol, 2024, 131:111917] | PubMed: 38527402 |
Carbon ion irradiation exerts antitumor activity by inducing cGAS-STING activation and immune response in prostate cancer-bearing mice [ Cancer Med, 2024, 13(2):e6950] | PubMed: 38379323 |
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [ Signal Transduct Target Ther, 2023, 8(1):371] | PubMed: 37735446 |
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [ Signal Transduct Target Ther, 2023, 8(1):371] | PubMed: 37735446 |
GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer [ Signal Transduct Target Ther, 2023, 8(1):48] | PubMed: 36725837 |
RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways [ Nat Commun, 2023, 14(1):6635] | PubMed: 37857628 |
RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways [ Nat Commun, 2023, 14(1):6635] | PubMed: 37857628 |
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury [ J Neuroinflammation, 2023, 20(1):222] | PubMed: 37777772 |
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury [ J Neuroinflammation, 2023, 20(1):222] | PubMed: 37777772 |
Human adenovirus infection induces pulmonary inflammatory damage by triggering noncanonical inflammasomes activation and macrophage pyroptosis [ Front Immunol, 2023, 14:1169968] | PubMed: 37180156 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。