C-176

製品コードS6575 バッチS657503

印刷

化学情報

Synonyms

N/A

Storage
(From the date of receipt)

3 years -20°C powder

化学式

C₁₁H₇IN₂O₄

分子量

358.09

CAS No.

314054-00-7

Solubility (25°C)*

体外

DMSO

72 mg/mL (201.06 mM)

Ethanol

1.5 mg/mL (4.18 mM)

Water

Insoluble

体内（毎回新しく調製した物を用意してください）

Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O この製剤はselleckのラボで検証済みです。上記の溶解方法がご要望を満たさない場合、selleckの営業担当までお問い合わせ頂ければ、個別の試験を行います。	0.895mg/ml (2.50mM)	Taking the 1 mL working solution as an example, add 50 μL of 17.9 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.
in vitro	C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. It directly targets mouse STING (mmSTING) but not human STING (hsSTING)^[1].
in vivo	C-176 attenuates STING-associated autoinflammatory disease in mice^[1].

プロトコル(参考用のみ)

細胞アッセイ	細胞株	H526 cells
	濃度	1 μM
	反応時間	48 h
	実験の流れ	Cells were treated 1 μM C176 and 1 μM AZD1775 for 48 h
動物実験	動物モデル	C57BL/6J mice
	投薬量	750 nmol/200 μL
	投与方法	ip

参考

https://pubmed.ncbi.nlm.nih.gov/29973723/
https://pubmed.ncbi.nlm.nih.gov/35584676/

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway [ Nat Commun, 2025, 16(1):289]	PubMed: 39753529
IL-17-producing γδ T cells in the tumor microenvironment promote radioresistance in mice [ J Clin Invest, 2025, e193945]	PubMed: 41055972
Cholesterol 25-Hydroxylase Enhances Myeloid-Derived Suppressor Cell (MDSC) Immunosuppression via the Stimulator of Interferon Genes (STING)-Tank-Binding Kinase 1 (TBK1)-Receptor-Interacting Protein Kinase 3 (RIPK3) Pathway in Colorectal Cancer [ MedComm (2020), 2025, 6(10):e70411]	PubMed: 41020041
Chronic Cellular NAD Depletion Activates a Viral Infection-Like Interferon Response Through Mitochondrial DNA Leakage [ Aging Cell, 2025, e70135]	PubMed: 40519092
Bleomycin promotes cellular senescence and activation of the cGAS-STING pathway without direct effect on fibrosis in an idiopathic pulmonary fibrosis model [ Aging (Albany NY), 2025, 17(8):2189-2211]	PubMed: 40882007
Stimulator of Interferon Genes Regulates Ferroptosis and Airway Inflammation via acyl-CoA Synthetase Long-Chain Family Member 4 in Asthmatic Mice [ Inflammation, 2025, 10.1007/s10753-025-02338-w]	PubMed: 40702384
Oral Lipid-Based Nanomedicine for the Inhibition of the cGAS-STING Pathway in Inflammatory Bowel Disease Treatment [ Mol Pharm, 2025, 10.1021/acs.molpharmaceut.4c01297]	PubMed: 40032274
PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPα/SYK/FcγR signalings in tumor associated macrophages [ Sci Rep, 2025, 15(1):2303]	PubMed: 39824849
Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways [ Invest Ophthalmol Vis Sci, 2025, 66(2):13]	PubMed: 39908129
MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis [ Nature, 2024, 625(7995):585-592]	PubMed: 38200309

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。