C-176

製品コードS6575 バッチS657504

印刷

化学情報

Chemical Structure Synonyms N/A Storage
(From the date of receipt)		 3 years -20°C powder
化学式

C11H7IN2O4
分子量 358.09 CAS No. 314054-00-7
Solubility (25°C)* 体外 DMSO 72 mg/mL (201.06 mM)
Ethanol 3 mg/mL (8.37 mM)
Water Insoluble
体内 （毎回新しく調製した物を用意してください）
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
1.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 12 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.
in vitro

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. It directly targets mouse STING (mmSTING) but not human STING (hsSTING)[1].
in vivo

C-176 attenuates STING-associated autoinflammatory disease in mice[1].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 H526 cells
濃度 1 μM
反応時間 48 h
実験の流れ

Cells were treated 1 μM C176 and 1 μM AZD1775 for 48 h
動物実験 動物モデル C57BL/6J mice
投薬量 750 nmol/200 μL
投与方法 ip

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Up-regulation of HSP90α in HDM-induced asthma causes pyroptosis of airway epithelial cells by activating the cGAS-STING-ER stress pathway [ Int Immunopharmacol, 2024, 131:111917] PubMed: 38527402
Carbon ion irradiation exerts antitumor activity by inducing cGAS-STING activation and immune response in prostate cancer-bearing mice [ Cancer Med, 2024, 13(2):e6950] PubMed: 38379323
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [ Signal Transduct Target Ther, 2023, 8(1):371] PubMed: 37735446
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [ Signal Transduct Target Ther, 2023, 8(1):371] PubMed: 37735446
GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer [ Signal Transduct Target Ther, 2023, 8(1):48] PubMed: 36725837
RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways [ Nat Commun, 2023, 14(1):6635] PubMed: 37857628
RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways [ Nat Commun, 2023, 14(1):6635] PubMed: 37857628
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury [ J Neuroinflammation, 2023, 20(1):222] PubMed: 37777772
Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury [ J Neuroinflammation, 2023, 20(1):222] PubMed: 37777772
Human adenovirus infection induces pulmonary inflammatory damage by triggering noncanonical inflammasomes activation and macrophage pyroptosis [ Front Immunol, 2023, 14:1169968] PubMed: 37180156

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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