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Synonyms | Storage (From the date of receipt) |
3 years-20°C powder | ||
化学式 | C45H69N11O12S |
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分子量 | 988.16 | CAS No. | 37025-55-1 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (101.19 mM) | |
Water | 100 mg/mL (101.19 mM) | |||
Ethanol | 100 mg/mL (101.19 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | Carbetocin Acetate is a long-acting oxytocin-analogue and a potent agonist of the oxytocin receptor (OXTR), with improved in vivo stability over oxytocin. | |||||
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in vitro | Carbetocin Acetate is a long-acting oxytocin-analogue and a potent agonist of the oxytocin receptor (OXTR), with higher affinity to the chimeric N-terminus (E1) receptor.[1] |
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in vivo | In the forced swim test, Carbetocin produces antidepressant-like changes in behavior via activation of oxytocin receptors in the CNS.[2] |
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密度 | 95.0~105.0% |
細胞アッセイ | 細胞株 | COS-7 cells |
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濃度 | 0.03-100 nM | |
反応時間 | ||
実験の流れ | COS-7 cells are cultured in DMEM with 10% (vol/vol) fetal calf serum. Subconfluent COS-7 cells are grown in 10 cm petri dishes and are transfected with the different expression plasmids by the DEAE-dextran method. Cell membranes are prepared and homogenized in 20 mM HEPES, pH 7.4. The protein content of the membranes is determined using bovine serum albumin as standard. Saturation and displacement assays are performed using [3H][Arg8]vasopressin or [3H]barusiban as radiolabelled ligand. Bound and free radioactivity is saparated by filtration. For competition experiments, 5-50 μg of membrane protein is used. Competition binding of 3 nM [3H][Arg8]vasopressin with unlabelled hormones in a concentration range from 0.03 nM to 100 μM is performed with barusiban as well as with the ligands [Arg8]vasopressin, oxytocin, carbetocin, and atosiban. Non-specific binding is determined in the presence of 3 μM unlabeled [Arg8]vasopressin. |
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動物実験 | 動物モデル | male Sprague-Dawley rats |
投薬量 | i.c.v.; 1, 10, 100 microg/rat, i.v.; 2.5, 5 mg/kg, i.p.; 2, 6.4, 20 mg/kg | |
投与方法 | i.c.v., i.v., i.p. |
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長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。