Caspofungin (MK-0991) Acetate

製品コードS3073 バッチS307306

化学情報

	Synonyms	L-743872	Storage (From the date of receipt)	3 years -20°C(in the dark) powder
	化学式	C₅₂H₈₈N₁₀O₁₅.2C₂H₄O₂
	分子量	1213.42	CAS No.	179463-17-3
Solubility (25°C)*	体外	DMSO	100 mg/mL (82.41 mM)
		Water	100 mg/mL (82.41 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明	Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1,3-glucan synthase inhibitor.
in vitro	Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of filamentous fungi. Prior studies have shown in vitro activity of caspofungin acetate using the reference methods, broth microdilution or macrodilution, for antifungal susceptibility testing of Candida species established by the National Committee for Clinical Laboratory Standards 1997 guidelines against a variety of Candida species including Candida krusei. Although caspofungin acetate is only Food and Drug Administration-approved for the treatment of aspergillosis, there is information showing that many Candida species are susceptible. The minimal inhibitory concentration for 90% inhibition of Candida species by caspofungin acetate are as follows:C. albicans 0.5 μg/mL (range, 0.25-0.5), C. glabrata 1.0 μg/mL (range, 0.25-2.0), C. tropicalis 1.0 μg/mL (range, 0.25-1.0), C. parapsilosis 0.5 μg/mL (range, 0.25-1.0), and C. krusei 2.0 μg/mL (range, 0.5-2.0)

製品説明

Caspofungin Acetate (MK-0991, L-743872) is an lipopeptide antifungal β-1,3-glucan synthase inhibitor.

in vitro

Caspofungin acetate is the first in a new class of antifungals that inhibits the synthesis of beta (1, 3)-d-glucan, an essential component of the cell wall of filamentous fungi. Prior studies have shown in vitro activity of caspofungin acetate using the reference methods, broth microdilution or macrodilution, for antifungal susceptibility testing of Candida species established by the National Committee for Clinical Laboratory Standards 1997 guidelines against a variety of Candida species including Candida krusei. Although caspofungin acetate is only Food and Drug Administration-approved for the treatment of aspergillosis, there is information showing that many Candida species are susceptible. The minimal inhibitory concentration for 90% inhibition of Candida species by caspofungin acetate are as follows:C. albicans 0.5 μg/mL (range, 0.25-0.5), C. glabrata 1.0 μg/mL (range, 0.25-2.0), C. tropicalis 1.0 μg/mL (range, 0.25-1.0), C. parapsilosis 0.5 μg/mL (range, 0.25-1.0), and C. krusei 2.0 μg/mL (range, 0.5-2.0)

プロトコル(参考用のみ)

細胞アッセイ	細胞株	Vero cells
	濃度	20.78 μM
	反応時間	2-3 days
	実験の流れ	Vero cells were treated with the indicated concentrations of drugs for 2- or 3-days incubation
動物実験	動物モデル	Complement component 5-deficient DBA/2N mice
	投薬量	1, 2, 4, or 8 mg/kg/day
	投与方法	i.p.

参考

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Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Antiviral Activity of Micafungin and Its Derivatives against SARS-CoV-2 RNA Replication [ Viruses, 2023, 15(2)452]	PubMed: 36851666
Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases [ BMC Med, 2022, 20(1):359]	PubMed: 36266654
Unique mechanistic insights into pathways associated with the synergistic activity of polymyxin B and caspofungin against multidrug-resistant Klebsiella pneumoniae [ Comput Struct Biotechnol J, 2022, 20:1077-1087]	PubMed: 35284046
Synergistic in-vitro antiviral effects of combination treatment using anidulafungin and T-1105 against Zika virus infection [ Antiviral Res, 2021, S0166-3542(21)00178-9]	PubMed: 34648875
Micafungin Inhibits Dengue Virus Infection through the Disruption of Virus Binding, Entry, and Stability [ Pharmaceuticals (Basel), 2021, 14(4)338]	PubMed: 33917182
Caspofungin Suppresses Brain Cell Necroptosis in Ischemic Stroke Rats via Up-Regulation of Pellino3 [ Cardiovasc Drugs Ther, 2021, 10.1007/s10557-021-07231-w]	PubMed: 34495409
Inhibiting Fungal Echinocandin Resistance by Small-Molecule Disruption of Geranylgeranyltransferase Type I Activity. [ Antimicrob Agents Chemother, 2020, 64(2)]	PubMed: 31791942
The fungal cell wall as a target for the development of new antifungal therapies. [ Biotechnol Adv, 2019, 37(6):107352]	PubMed: 30797093
Anti-fungal activity of a novel triazole, PC1244, against emerging azole-resistant Aspergillus fumigatus and other species of Aspergillus. [ J Antimicrob Chemother, 2019, 74(10):2950-2958]	PubMed: 31361006
Antifungal Activity in Compounds from the Australian Desert Plant Eremophila alternifolia with Potency Against Cryptococcus spp. [ Antibiotics (Basel), 2019, 8(2)]	PubMed: 30935155

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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