(+)-Catechin

製品コードS4722 バッチS472202

印刷

化学情報

Chemical Structure Synonyms Cianidanol, Catechinic acid, Catechuic acid, Catechin Storage
(From the date of receipt)		 3 years -20°C powder (seal)
化学式

C15H14O6
分子量 290.27 CAS No. 154-23-4
Solubility (25°C)* 体外 DMSO 58 mg/mL (199.81 mM)
Ethanol 58 mg/mL (199.81 mM)
Water 4 mg/mL (13.78 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 (+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
in vitro The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins[1]. Treatment of human prostate cancer cells with catechin induces apoptosis and results in effects on a variety of survival signals suggesting the potential of these compounds as chemopreventive agents for prostate cancer[2]. Catechin is well known to inhibit cyclooxygenase activity with reported IC50 values ranging from 4O μM to 943 μM. It has also been reported to act as an inhibitor of COX-1 and COX-2 with IC50 of about 80 µM and 130 μM[3].
in vivo Dietary catechin significantly delayed tumor onset[5]. Continued intake of catechin, a potential antioxidant, prevents memory regression and DNA oxidative damage in senescence-accelerated (SAMP10) mice. It does not prolong the lifetime of SAMP10 mice, but it does delay brain senescence[6]. (+)-Catechin inhibits intestinal tumor formation and suppresses Focal adhesion kinase activation in the Min/+ Mouse[7].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 LB02 tumor cell line
濃度 10, 50, 100 or 200 μg/mL
反応時間 48 h
実験の流れ

LB02 cells were resuspended in RPMI 10% FBS in a concentration of 5x105 cells/mL. The cultures were performed in 96-well round-bottomed microtitre plates in presence of different concentrations of catechin or rutin (10, 50, 100 or 200 μg/mL). After 48 h at 37 ºC in a humidified atmosphere with 5% CO2 in the air, cultures were pulsed with 1 μCi of 3H-thymidine/well and maintained for an additional 18 h period prior to a semiautomatic method harvest.
動物実験 動物モデル Kunming mice
投薬量 1, 2, 3 mg/kg
投与方法 stomach perfusion

Selleckの高級品が、幾つかの出版された研究調査結果（以下を含む）で使われた：

Systematic pharmacology-based strategy to explore the mechanism of Semen Strychni for treatment of papillary thyroid carcinoma [ Sci Rep, 2023, 13(1):18492.] PubMed: 37898675
Systematic pharmacology-based strategy to explore the mechanism of Semen Strychni for treatment of papillary thyroid carcinoma [ Sci Rep, 2023, 13(1):18492] PubMed: 37898675
Systematic pharmacology-based strategy to explore the mechanism of Semen Strychni for treatment of papillary thyroid carcinoma [ Sci Rep, 2023, 10.1038/s41598-023-45741-9] PubMed: 37898675
(-)-Epicatechin acts as a potent agonist of the membrane androgen receptor, ZIP9 (SLC39A9), to promote apoptosis of breast and prostate cancer cells [ J Steroid Biochem Mol Biol, 2021, 211:105906] PubMed: 33989703

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

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