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Synonyms | Curaxin-137, CBL-C137, CBLC137 | Storage (From the date of receipt) |
3 years -20°C powder | |
化学式 | C21H24N2O2 |
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分子量 | 336.43 | CAS No. | 1197996-80-7 | |
Solubility (25°C)* | 体外 | DMSO | 15 mg/mL (44.58 mM) | |
Ethanol | 8 mg/mL (23.77 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
製品説明 | CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively. |
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SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis [ JCI Insight, 2023, 8(4)e154120] | PubMed: 36810256 |
CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells [ Biomed Pharmacother, 2023, 161:114529] | PubMed: 37002567 |
SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes [ Nat Cancer, 2022, 3(2):188-202] | PubMed: 35115713 |
Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation [ Cancer Lett, 2021, 520:201-212] | PubMed: 34271103 |
The small molecule drug CBL0137 increases the level of DNA damage and the efficacy of radiotherapy for glioblastoma [ Cancer Lett, 2021, 499:232-242] | PubMed: 33253788 |
HeLa TI cell-based assay as a new approach to screen for chemicals able to reactivate the expression of epigenetically silenced genes [ PLoS One, 2021, 16(6):e0252504] | PubMed: 34115770 |
Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization [ Cells, 2020, 9(6):1423] | PubMed: 32521766 |
長期の保管のために-20°Cの下で製品を保ってください。
人間や獣医の診断であるか治療的な使用のためにでない。
各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。