Cefradine

製品コードS4671 バッチS467101

印刷

化学情報

Chemical Structure Synonyms Cephradine, Sefril, Anspor, Cephradin, Velosef Storage
(From the date of receipt)		 3 years -20°C powder
1 years -80°C in solvent
化学式

C16H19N3O4S
分子量 349.4 CAS No. 38821-53-3
Solubility (25°C)* 体外 Water 10 mg/mL (28.62 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

溶剤液（一定の濃度）を調合する

生物活性

製品説明 Cefradine (Cephradine, Sefril, Anspor, Velosef) is a semi-synthetic cephalosporin antibiotic.
in vivo Cephradine has a low order of acute, subacute, and chronic oral toxicity, and acute and subacute parenteral toxicity. After daily intravenous doses of cephradine has been given to monkeys for 2 weeks, these animals show no signs of nephrotoxicity. Cephradine does not induce any teratogenic changes in the offspring of either mice or rats. The route of administration has been a determinant in the choice of a cephalosporin antibiotic. It is a distinct therapeutic advantage that a single cephalosporin antibiotic, cephradine, may be used in both oral and parenteral preparations[2].

プロトコル(参考用のみ)

細胞アッセイ 細胞株 CHO/hPEPT1 cells
濃度 1 mg/mL
反応時間 10, 20, 30, 45, 60, 90 min
実験の流れ

Cells Are seeded in six-well culture plates (9.6 cm2, growth area) at a density of 105 cells/cm2. At 2 days postseeding, the medium is removed and cells are washed twice with pH 6.0 uptake buffer. Independent studies are performed for each drug solution at 1 mg/mL made in pH 6.0 uptake buffer. At each time point (10, 20, 30, 45, 60, 90 min), drug solution is removed and cells are washed three times with ice-cold pH 6.0 uptake buffer. One milliliter of Milli-Q water is added to each well and incubated for 30 min at 25 °C. Cells are harvested and sonicated for 1-2 min. ZnSO4 solution (8%, 200 mL) is added to the cell lysate, vortexed rigorously, and centrifuged for 5 min at 3000 rpm. After filtration of the supernatant through a membrane filter (0.45 mm), samples are analyzed by HPLC.
動物実験 動物モデル Charles River CD Sprague-Dawley rats
投薬量 100, 300, or 1,000 mg/kg
投与方法 p.o.

参考

  • https://pubmed.ncbi.nlm.nih.gov/10052994/
  • https://pubmed.ncbi.nlm.nih.gov/4790617/

長期の保管のために-20°Cの下で製品を保ってください。

人間や獣医の診断であるか治療的な使用のためにでない。

各々の製品のための特定の保管と取扱い情報は、製品データシートの上で示されます。大部分のSelleck製品は、推薦された状況の下で安定です。製品は、推薦された保管温度と異なる温度で、時々出荷されます。長期の保管のために必要とされてそれと異なる温度で、多くの製品は、短期もので安定です。品質を維持するが、夜通しの積荷のために最も経済的な貯蔵状況を用いてあなたの送料を保存する状況の下に、製品が出荷されることを、我々は確実とします。製品の受領と同時に、製品データシートの上で貯蔵推薦に従ってください。